Prognostic Value for Perioperative Serum Total Cholesterol Level on Postoperative Long-Term Prognosis of Pancreatic Cancer: A Retrospective Clinical Study

Cholesterol correlates with occurrence and progression of pancreatic cancer and has predictive value for postoperative prognosis in various cancers. Our study intended to reveal the relationship between perioperative serum total cholesterol (TC) level and postoperative prognosis of pancreatic cancer...

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Bibliographic Details
Published in:Diagnostics (Basel) 2023-04, Vol.13 (8), p.1402
Main Authors: Wang, Han-Xuan, Ding, Cheng, Huang, Jin-Can, Ma, You-Wei, Lyu, Shao-Cheng, Lang, Ren
Format: Article
Language:English
Subjects:
Abdomen
Cancer therapies
Chemotherapy
Cholesterol
Embolisms
Fistula
Health aspects
Hospitals
long-term prognosis
Medical prognosis
Metastasis
Pancreatic cancer
Patients
postoperative
predictive value
Prognosis
serum cholesterol level
Surgery
Surgical outcomes
Tumors
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Summary:Cholesterol correlates with occurrence and progression of pancreatic cancer and has predictive value for postoperative prognosis in various cancers. Our study intended to reveal the relationship between perioperative serum total cholesterol (TC) level and postoperative prognosis of pancreatic cancer. We retrospectively analyzed the data of pancreatic cancer patients who underwent surgical treatment at our hospital from January 2015 to December 2021. ROC curves between serum TC level at each time point and 1-year survival rate were drawn, from which study object and optimal cutoff value was determined. Patients were divided into low and high-TC groups, and perioperative data and prognosis were compared. Risk factors for poor postoperative prognosis were identified by univariate and multivariate analysis. Overall survival rates at postoperative 1, 2 and 3 years in the low and high-TC groups were 52.9%, 29.4%, and 15.6% and 80.4%, 47.2%, and 33.8% ( = 0.005), respectively. Multivariate analysis confirmed tumor differentiation degree ( = 2.054, 95% CI: 1.396-3.025), pTNM stage ( = 1.595, 95% CI: 1.020-2.494), lymph node metastasis ( = 1.693, 95% CI: 1.127-2.544), and postoperative 4-week serum TC level ( = 0.663, 95% CI: 0.466-0.944) as independent risk factors for prognosis of pancreatic cancer. We conclude that postoperative 4-week serum TC level has certain predictive value for long-term postoperative prognosis of pancreatic cancer.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13081402