Elevated Immunoglobulin E Serum Levels: Possible Underlying Factors That Can Cause an Inborn Error of Immunity in the Pediatric Population with Recurrent Infections

Elevated immunoglobulin E (IgE) levels are commonly associated with allergies. However, high IgE levels are also found in several other infectious and non-infectious disorders. Elevated IgE levels typically suggest allergies, eczema, or recurrent skin infections. Hyperimmunoglobulin E (hyper-IgE) le...

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Bibliographic Details
Published in:Antibodies (Basel) 2024-06, Vol.13 (2), p.47
Main Authors: Oprițescu, Sînziana, Nițescu, Gabriela Viorela, Cîrnațu, Daniela, Trifunschi, Svetlana, Munteanu, Melania, Golumbeanu, Mihaela, Boghițoiu, Dora, Dărăban, Adriana Maria, Ilie, Elena Iuliana, Moroșan, Elena
Format: Article
Language:English
Subjects:
Age
Allergens
Allergies
Atopy
Bacterial diseases
Children
clinical manifestation
COVID-19
Diagnosis
Diseases
Eczema
Genetic disorders
Health aspects
HIES
Hospitals
hyper-IgE
Immunoglobulin E
Immunoglobulins
Immunology
Infections
Infectious diseases
Kidney diseases
Mutation
Patients
Pediatrics
Phenotypes
Risk factors
Serum levels
Skin diseases
Viral infections
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Summary:Elevated immunoglobulin E (IgE) levels are commonly associated with allergies. However, high IgE levels are also found in several other infectious and non-infectious disorders. Elevated IgE levels typically suggest allergies, eczema, or recurrent skin infections. Hyperimmunoglobulin E (hyper-IgE) levels typically reflect a monogenic atopic condition or inborn immune defects with an atopic phenotype. The aim of our research is to investigate and observe the clinical characteristics of children with increased IgE levels who have previously manifested infectious diseases. Furthermore, the retrospective study considers other factors, such as demographic characteristics (sex, area/environment, and age), and their effect on IgE serum levels. To answer this question, we conducted a one-year hospital-based retrospective study that included 200 hospitalized children who had at least two viral or bacterial infections in the six months preceding hospitalization. Measurements of IgE and allergen panels (respiratory and digestive) using blood samples revealed that individuals who tested positive for the body's synthesis of hyper-IgE were not observably allergic to any potential allergens despite having higher total serum IgE. According to the results, there was a strong correlation between elevated IgE serum levels and a history of infectious diseases among the patients.
ISSN:2073-4468
2073-4468
DOI:10.3390/antib13020047