Cytospyrone and Cytospomarin: Two New Polyketides Isolated from Mangrove Endophytic Fungus, Cytospora sp

Two new polyketides, cytospyrone ( ), cytospomarin ( ), together with three known metabolites dimethoxyphtalide ( ), integracin A ( ) and integracin B ( ), were isolated from the culture of sp. from the Chinese mangrove . Their structures were elucidated by extensive spectroscopic analyses and time...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-09, Vol.25 (18), p.4224
Main Authors: Wei, Chengwen, Deng, Qin, Sun, Mengyu, Xu, Jing
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Anti-Infective Agents - isolation & purification
Anti-Infective Agents - pharmacology
antimicrobial activity
Ascomycota - chemistry
Ascomycota - metabolism
Cell Survival - drug effects
Circular Dichroism
Cytospora sp
cytotoxicity
Density Functional Theory
Escherichia coli - drug effects
Hep G2 Cells
Humans
Microbial Sensitivity Tests
Molecular Conformation
polyketides
Polyketides - chemistry
Polyketides - isolation & purification
Polyketides - pharmacology
structure identification
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Summary:Two new polyketides, cytospyrone ( ), cytospomarin ( ), together with three known metabolites dimethoxyphtalide ( ), integracin A ( ) and integracin B ( ), were isolated from the culture of sp. from the Chinese mangrove . Their structures were elucidated by extensive spectroscopic analyses and time dependent density functional theory (TDDFT), calculation of electronic circular dichroism (ECD) and optical rotation (OR) data. Compound displayed weak inhibitory activity against GIM1.201 (minimum inhibitory concentration (MIC) value of 0.35 mM). Compounds and displayed significant cytotoxicity against human cancer cell line HepG2 (IC values of 5.98 ±  0.12 µM and 9.97 ± 0.06 µM, respectively), more potent than the positive control 5-fluorouracil (IC value of 43.50 ± 3.69 µM).
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25184224