Prognostic significance of FA score based on plasma fibrinogen and serum albumin in patients with epithelial ovarian cancer

To evaluate the significance of fibrinogen and albumin (FA) score based on preoperative peripheral blood plasma fibrinogen and serum albumin in the prognosis of patients with epithelial ovarian cancer (EOC). Patients' clinicopathological data of 186 cases of EOC were retrospectively collected,...

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Bibliographic Details
Published in:Cancer management and research 2019-08, Vol.11, p.7697-7705
Main Authors: Li, Yuan, Yang, Jia-Ni, Cheng, Shan-Shan, Wang, Yu
Format: Article
Language:English
Subjects:
Albumin
Analysis
C-reactive protein
Cancer metastasis
Cancer patients
Care and treatment
Development and progression
Epithelial ovarian cancer
Fibrin
Fibrinogen
Lymphocytes
Medical research
Medical schools
Original Research
Ovarian cancer
Prognosis
Surgery
Tumors
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Summary:To evaluate the significance of fibrinogen and albumin (FA) score based on preoperative peripheral blood plasma fibrinogen and serum albumin in the prognosis of patients with epithelial ovarian cancer (EOC). Patients' clinicopathological data of 186 cases of EOC were retrospectively collected, and these patients were divided into three groups according to their FA scores (both plasma fibrinogen and serum albumin abnormal were allocated a score of 2; one of them abnormal were allocated a score of 1; neither of them abnormal were allocated a score of 0; optimal cut-off point is taken as the critical point whether the value is abnormal or not). Correlation between FA score in patients with EOC as well as clinicopathological features and overall survival (OS) was analyzed. (1) Receiver operating characteristic curve showed that the optimal cut-off point of plasma fibrinogen in the preoperative peripheral blood of patients with EOC was 3.63 g/L. The optimal cut-off point for serum albumin level was 42.45 g/L. (2) There was no significant difference in age, tumor size, neutrophil count, lymphocyte count, C reactive protein and preoperative tumor marker CA125 between the three groups (FA score=0, FA score=1, FA score=2) ( >0.05). However, there was statistically significant difference in tumor grade, tumor stage and the presence of lymph node metastasis between different FA scoring groups (
ISSN:1179-1322
1179-1322
DOI:10.2147/CMAR.S211524