The traditional Chinese medicines treat chronic heart failure and their main bioactive constituents and mechanisms

Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and mortality, any treatment targeting a single session is insufficient to tackle this. CHF is characterized by reduced cardiac output resulting from neurohumoral dysregulation and cardiac remodeling, which might...

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Bibliographic Details
Published in:Acta pharmaceutica Sinica. B 2023-05, Vol.13 (5), p.1919-1955
Main Authors: Chen, Jie, Wei, Xiaohong, Zhang, Qian, Wu, Yuzhuo, Xia, Guiyang, Xia, Huan, Wang, Lingyan, Shang, Hongcai, Lin, Sheng
Format: Article
Language:English
Subjects:
Cardiac remodeling
Chinese medicinal herbs
Chronic heart failure
Constituent compatibility
Multiple targets
Natural ingredients
Review
Synergistic effects
Traditional Chinese medicine formula
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Summary:Chronic heart failure (CHF) is a severe public health problem with increasing morbidity and mortality, any treatment targeting a single session is insufficient to tackle this. CHF is characterized by reduced cardiac output resulting from neurohumoral dysregulation and cardiac remodeling, which might be related to oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, autophagy, mitochondrial function, and angiogenesis. These molecular mechanisms interact with each other through crosstalk. Historically, Chinese medicinal herbs have been widely applied in the treatment of CHF, and therapeutic effects of Chinese medicinal herbs and their ingredients have been scientifically confirmed over the past decades. Traditional Chinese medicine (TCM) with multiple components can confront the different pathogenesis of CHF through multiple targets. This review analyzes commonly used TCM patent drugs and TCM decoctions that are applicable to different stages of CHF based on clinical trials. Diverse bioactive ingredients in Chinese medicinal herbs have been found to treat CHF via multiple molecular mechanisms. This review comprehensively covers the key works on the effects and underlying mechanisms of TCM, herbal ingredients and synergistic effects of constituent compatibility in treating CHF, providing additional ideas to address this threat. This review provides the progress of traditional Chinese herbal medicines and their ingredients against chronic heart failure from the perspective of clinical evidence and preclinical evidence. [Display omitted]
ISSN:2211-3835
2211-3843
DOI:10.1016/j.apsb.2023.02.005