Antiproliferative Effect of Inorganic and Organic Selenium Compounds in Breast Cell Lines

Triple-negative breast cancer (TNBC) is an aggressive, fast-growing tumor that is more likely to spread to distant organs. Among women diagnosed with breast cancer, the prevalence of TNBC is 20%, and treatment is currently limited to chemotherapy. Selenium (Se), an essential micronutrient, has been...

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Published in:Biomedicines 2023-05, Vol.11 (5), p.1346
Main Authors: da Costa, Nayara Souza, Lima, Luíza Siqueira, Oliveira, Franciele Aparecida Mendes, Galiciolli, Maria Eduarda Andrade, Manzano, Mariana Inocêncio, Garlet, Quelen Iane, Irioda, Ana Carolina, Oliveira, Cláudia Sirlene
Format: Article
Language:English
Subjects:
Apoptosis
Breast cancer
Cancer
Cancer therapies
Cell adhesion & migration
Cell growth
cell line
Cell migration
Cell viability
Chemotherapy
Estrogens
Health aspects
Metastasis
Mutation
Selenium
Selenium compounds
Selenomethionine
Sodium
Sodium selenate
Sodium selenite
trace element
triple-negative breast cancer
Tumor cell lines
Tumors
Womens health
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Summary:Triple-negative breast cancer (TNBC) is an aggressive, fast-growing tumor that is more likely to spread to distant organs. Among women diagnosed with breast cancer, the prevalence of TNBC is 20%, and treatment is currently limited to chemotherapy. Selenium (Se), an essential micronutrient, has been explored as an antiproliferative agent. Therefore, this study aimed to evaluate the effects of exposure to organic (selenomethionine, ebselen, and diphenyl diselenide) and inorganic (sodium selenate and sodium selenite) Se molecules in different breast cell lines. The compounds were tested at 1, 10, 50, and 100 μM for 48 h in the non-tumor breast cell line (MCF-10A) and TNBC derivatives cell lines (BT-549 and MDA-MB-231). The effects of Se on cell viability, apoptotic and necrotic processes, colony formation, and cell migration were analyzed. Exposure to selenomethionine and selenate did not alter the evaluated parameters. However, selenomethionine had the highest selectivity index (SI). The exposure to the highest doses of selenite, ebselen, and diphenyl diselenide resulted in antiproliferative and antimetastatic effects. Selenite had a high SI to the BT cell line; however, the SI of ebselen and diphenyl diselenide was low in both tumoral cell lines. In conclusion, the Se compounds had different effects on the breast cell lines, and additional tests are needed to reveal the antiproliferative effects of Se compounds.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11051346