Inositol Derivatives and Phenolic Compounds from the Roots of Taraxacum coreanum

• Published in: Molecules (Basel, Switzerland) Switzerland), 2017-08, Vol.22 (8), p.1349
• Main Authors: Mo, Eun Jin, Ahn, Jong Hoon, Jo, Yang Hee, Kim, Seon Beom, Hwang, Bang Yeon, Lee, Mi Kyeong
• Format: Article
• Language: English
• Subjects: Acids; Alcohols; antioxidant; Antioxidants - chemistry; Antioxidants - pharmacology; Biological activity; Chromatography, High Pressure Liquid - methods; Coumarins - chemistry; Furans - chemistry; Glucosides - chemistry; Humans; Hydroxybenzaldehydes; Inhibitory Concentration 50; Inositol; Inositol - chemistry; Inositol - isolation & purification; Inositol 1,4,5-trisphosphate receptors; Lignans; Lignans - chemistry; Magnetic Resonance Spectroscopy - methods; Phenol - chemistry; Phenol - isolation & purification; phenolic; Phenolic compounds; Phenols; Phenylacetic acid; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Roots - chemistry; Receptors, Scavenger - chemistry; Receptors, Scavenger - metabolism; Roots; Syringaldehyde; Taraxacum - chemistry; Taraxacum coreanum; Vanillic acid; Vanillin
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules22081349

In this study, the characterization of chemical constituents and biological activity of the roots of (Asteraceae) was attempted. Phytochemical investigation of the roots of led to the isolation of two new inositol derivatives, taraxinositols A ( ) and B ( ), and a new phenolic compound, taraxinol ( ), together with twenty known compounds including four inositol derivatives, -inositol-1,4-bis (4-hydroxybenzeneacetate) ( ), -inositol-1,5-bis(4- hydroxybenzeneacetate) ( ), -inositol-2,3-bis (4-hydroxybenzeneacetate) ( ) and -inositol- 1,2,3-tris (4-hydroxybenzeneacetate) ( ), nine phenolic compounds: -hydroxybenzaldehyde ( ), vanillin ( ), syringaldehyde ( ), vanillic acid ( ), 4-methoxyphenylacetic acid ( ), 4-hydroxy- phenylacetic acid methyl ester ( ), optivanin ( ), isoferulic acid ( ) and dihydroconiferyl alcohol ( ), four coumarins: nodakenetin ( ), decursinol ( ), prangol ( ) and isobyakangelicin ( ), and three lignans: syringaresinol-4'- -β-d-glucoside ( ), syringaresinol ( ), and pinoresinol ( ). The structures of isolated compounds were determined on the basis of spectroscopic analysis. Among the isolated compounds, vanillic acid, isoferulic acid and syringaresinol showed radical scavenging activity with IC values ranging from 30.4 to 75.2 μM.