Prenatal and Postnatal Choline Supplementation in Fetal Alcohol Spectrum Disorder

Fetal alcohol spectrum disorder (FASD) is common and represents a significant public health burden, yet very few interventions have been tested in FASD. Cognitive deficits are core features of FASD, ranging from broad intellectual impairment to selective problems in attention, executive functioning,...

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Bibliographic Details
Published in:Nutrients 2022-02, Vol.14 (3), p.688
Main Authors: Ernst, Abigail M, Gimbel, Blake A, de Water, Erik, Eckerle, Judith K, Radke, Joshua P, Georgieff, Michael K, Wozniak, Jeffrey R
Format: Article
Language:English
Subjects:
Attention deficit hyperactivity disorder
Behavior
Brain
Brain injury
Child
Choline
Cognition & reasoning
Comorbidity
COVID-19
Dietary Supplements
DNA methylation
Ethanol - adverse effects
Executive function
Female
fetal alcohol spectrum disorders
Fetal Alcohol Spectrum Disorders - prevention & control
Fetal Alcohol Spectrum Disorders - psychology
Fetal alcohol syndrome
Gene expression
Humans
Intervention
Iron
Literature reviews
Longitudinal studies
Medical imaging
Memory
Motor ability
Motor skill
Nutrients
Optimization
Pregnancy
Prenatal experience
Public health
randomized controlled trials
Review
Reviews
Sensorimotor integration
Social interactions
Visual perception
Vitamins
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Summary:Fetal alcohol spectrum disorder (FASD) is common and represents a significant public health burden, yet very few interventions have been tested in FASD. Cognitive deficits are core features of FASD, ranging from broad intellectual impairment to selective problems in attention, executive functioning, memory, visual-perceptual/motor skills, social cognition, and academics. One potential intervention for the cognitive impairments associated with FASD is the essential nutrient choline, which is known to have numerous direct effects on brain and cognition in both typical and atypical development. We provide a summary of the literature supporting the use of choline as a neurodevelopmental intervention in those affected by prenatal alcohol. We first discuss how alcohol interferes with normal brain development. We then provide a comprehensive overview of the nutrient choline and discuss its role in typical brain development and its application in the optimization of brain development following early insult. Next, we review the preclinical literature that provides evidence of choline's potential as an intervention following alcohol exposure. Then, we review a handful of existing human studies of choline supplementation in FASD. Lastly, we conclude with a review of practical considerations in choline supplementation, including dose, formulation, and feasibility in children.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14030688