Vanadium and Melanoma: A Systematic Review

The application of metals in biological systems has been a rapidly growing branch of science. Vanadium has been investigated and reported as an anticancer agent. Melanoma is the most aggressive type of skin cancer, the incidence of which has been increasing annually worldwide. It is of paramount imp...

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Bibliographic Details
Published in:Metals (Basel ) 2021-05, Vol.11 (5), p.828
Main Authors: Amante, Cristina, De Sousa-Coelho, Ana Luísa, Aureliano, Manuel
Format: Article
Language:English
Subjects:
Anticancer properties
Brain research
Cadmium
cancer
Cancer therapies
Clinical trials
Cobalt
Coordination compounds
Europium
Europium compounds
In vivo methods and tests
Kinases
Melanoma
Metabolism
Metals
Mutation
Nanoparticles
Polysaccharides
Ruthenium
Ruthenium compounds
Severe acute respiratory syndrome coronavirus 2
Skin cancer
Systematic review
vanadate
Vanadates
vanadium
vanadium complexes
Vanadium compounds
vanadium nanoparticles
Vanadium pentoxide
Yttrium
Zinc
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Summary:The application of metals in biological systems has been a rapidly growing branch of science. Vanadium has been investigated and reported as an anticancer agent. Melanoma is the most aggressive type of skin cancer, the incidence of which has been increasing annually worldwide. It is of paramount importance to identify novel pharmacological agents for melanoma treatment. Herein, a systematic review of publications including “Melanoma and Vanadium” was performed. Nine vanadium articles in several melanoma cells lines such as human A375, human CN-mel and murine B16F10, as well as in vivo studies, are described. Vanadium-based compounds with anticancer activity against melanoma include: (1) oxidovanadium(IV); (2) XMenes; (3) vanadium pentoxide, (4) oxidovanadium(IV) pyridinonate compounds; (5) vanadate; (6) polysaccharides vanadium(IV/V) complexes; (7) mixed-metal binuclear ruthenium(II)–vanadium(IV) complexes; (8) pyridoxal-based oxidovanadium(IV) complexes and (9) functionalized nanoparticles of yttrium vanadate doped with europium. Vanadium compounds and/or vanadium materials show potential anticancer activities that may be used as a useful approach to treat melanoma.
ISSN:2075-4701
2075-4701
DOI:10.3390/met11050828