rs2476601 in PTPN22 gene in rheumatoid arthritis and periodontitis-a possible interface?

Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), CTLA4 genes (rs3087243) and its impact on RA and PD. In the study 111 RA patients and 256...

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Bibliographic Details
Published in:Journal of translational medicine 2020-10, Vol.18 (1), p.389-389, Article 389
Main Authors: Schulz, Susanne, Zimmer, Pauline, Pütz, Natalie, Jurianz, Elisa, Schaller, Hans-Günter, Reichert, Stefan
Format: Article
Language:English
Subjects:
Alleles
Arthritis, Rheumatoid - genetics
Autoimmune diseases
Cardiovascular disease
Case-Control Studies
CTLA-4 protein
CTLA4
Deoxyribonucleic acid
DNA
Enzymes
Etiology
Gene Frequency - genetics
Genes
Genetic diversity
Genetic factors
Genetic Predisposition to Disease
Genotype
Gum disease
Health risk assessment
Humans
Inflammatory diseases
Manufacturers
PADI4
Periodontitis
Periodontitis - genetics
Physiology
Polymorphism, Single Nucleotide - genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics
Protein-arginine deiminase
Protein-tyrosine-phosphatase
Proteins
PTPN22
Rheumatoid arthritis
Rheumatology
SNP
Teeth
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Summary:Rheumatoid arthritis (RA) and periodontitis (PD) are proven to share common risk markers, including genetic factors. In the present study we focused on genetic variants in PTPN22 (rs2476601), PADI4 (rs2240340), CTLA4 genes (rs3087243) and its impact on RA and PD. In the study 111 RA patients and 256 systemically healthy controls were involved. A subdivision of patients and controls was carried out according the severity of periodontitis (no/level 1 PD vs. level 2 PD). I. Evaluating the genetic impact on the occurrence of RA the T allele of rs2476601 (PTPN22) (bivariate: p 
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-020-02548-w