ADAMTS-13 and HMGB1-induced oxidative stress in Taenia multiceps-infected animals

This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis ( Taenia multiceps ). ADAMTS-13, HMGB1, glutathione reductase (GR...

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Bibliographic Details
Published in:Scientific reports 2023-10, Vol.13 (1), p.17929-17929, Article 17929
Main Authors: Dincel, Gungor Cagdas, Yavuz, Orhan, Yildirim, Serkan, Al-Olayan, Ebtesam M., El-Ashram, Saeed
Format: Article
Language:English
Subjects:
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8-Hydroxydeoxyguanosine
ADAM protein
Animals
Blood-brain barrier
Copper
Cytotoxicity
Deoxyguanosine
Endothelial cells
Glial cells
Glutathione reductase
Health risks
HMGB1 protein
Humanities and Social Sciences
multidisciplinary
Neuronal-glial interactions
Neuropathogenesis
Neuropathy
Neuroprotection
Oxidative stress
Risk assessment
Science
Science (multidisciplinary)
Taenia multiceps
Therapeutic targets
Thrombospondin
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Summary:This study investigated the cytotoxic effects of oxidative stress (OS), high mobility group box 1 (HMGB1), ADAMTS (A disintegrin and metalloproteinase with thrombospondin motifs), and neuropathology associated with coenurus cerebralis ( Taenia multiceps ). ADAMTS-13, HMGB1, glutathione reductase (GR), copper/zinc superoxide dismutase (Cu/Zn SOD), and 8-hydroxy-2'-deoxyguanosine (8-OHdG) expression levels were studied. The study found that ADAMTS-13 ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-44376-0