Microrobot with Gyroid Surface and Gold Nanostar for High Drug Loading and Near-Infrared-Triggered Chemo-Photothermal Therapy

The use of untethered microrobots for precise synergistic anticancer drug delivery and controlled release has attracted attention over the past decade. A high surface area of the microrobot is desirable to achieve greater therapeutic effect by increasing the drug load. Therefore, various nano- or mi...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2022-11, Vol.14 (11), p.2393
Main Authors: Zheng, Shirong, Hoang, Manh Cuong, Nguyen, Van Du, Go, Gwangjun, Nan, Minghui, Darmawan, Bobby Aditya, Kim, Seokjae, Im, Seung-hyun, Lee, Taeksu, Bang, Doyeon, Park, Jong-Oh, Choi, Eunpyo
Format: Article
Language:English
Subjects:
Antimitotic agents
Antineoplastic agents
Blood vessels
Cancer
chemo-photothermal therapy
Chemotherapy
Design
Dosage and administration
Drug delivery systems
drug loading
Drugs
Efficiency
Energy
Gold
Gyroid surface
Health aspects
Infrared radiation
Lasers
Magnetic fields
microrobot
Nanoparticles
Pharmaceutical research
Phototherapy
Polymerization
Robots
Scanning electron microscopy
Spectrum analysis
Technology application
Vehicles
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The use of untethered microrobots for precise synergistic anticancer drug delivery and controlled release has attracted attention over the past decade. A high surface area of the microrobot is desirable to achieve greater therapeutic effect by increasing the drug load. Therefore, various nano- or microporous microrobot structures have been developed to load more drugs. However, as most porous structures are not interconnected deep inside, the drug-loading efficiency may be reduced. Here, we propose a magnetically guided helical microrobot with a Gyroid surface for high drug-loading efficiency and precise drug delivery. All spaces inside the proposed microrobot are interconnected, thereby enabling drug loading deep inside the structure. Moreover, we introduce gold nanostars on the microrobot structure for near-infrared-induced photothermal therapy and triggering drug release. The results of this study encourage further exploration of a high loading efficiency in cell-based therapeutics, such as stem cells or immune cells, for microrobot-based drug-delivery systems.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14112393