Synthesis of Heteroannulated Indolopyrazines through Domino N–H Palladium-Catalyzed/Metal-Free Oxidative C–H Bond Activation

A convenient approach to [1,2,5]­oxadiazolo­[3′,4′:5,6]­pyrazino­[2,3-b]­indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald–Hartwig and subsequent annulation by intramolecular oxi...

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Bibliographic Details
Published in:ACS omega 2020-06, Vol.5 (25), p.15681-15690
Main Authors: Kvashnin, Yuriy A, Verbitskiy, Egor V, Zhilina, Ekaterina F, Rusinov, Gennady L, Chupakhin, Oleg N, Charushin, Valery N
Format: Article
Language:English
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Summary:A convenient approach to [1,2,5]­oxadiazolo­[3′,4′:5,6]­pyrazino­[2,3-b]­indoles and their heteroannulated analogues bearing various aryl substituents in the backbone has been developed. This synthetic protocol is based on Pd-catalyzed Buchwald–Hartwig and subsequent annulation by intramolecular oxidative cyclodehydrogenation. The photophysical properties for new polycycles have been measured.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.0c01945