RNA Editing and Drug Discovery for Cancer Therapy

RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for...

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Bibliographic Details
Published in:TheScientificWorld 2013-01, Vol.2013 (2013), p.1-5
Main Authors: Liang, Shih-Shin, Yang, Cheng-Hong, Tang, Jen-Yang, Tseng, Chao-Neng, Huang, Wei-Hsuan, Chang, Hsueh-Wei
Format: Article
Language:English
Subjects:
Amino acids
Animals
Bioinformatics
Cancer
Cancer therapies
Care and treatment
Drug discovery
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Gene Expression Regulation, Neoplastic - genetics
Genetic research
Genetic Therapy - methods
Humans
Literature reviews
Models, Biological
Molecules
Natural products
Neoplasm Proteins - genetics
Neoplasms - drug therapy
Neoplasms - genetics
Oncology, Experimental
R&D
Research & development
Review
Ribonucleic acid
RNA
RNA Editing - genetics
RNA sequencing
Stem cells
Target recognition
Therapy
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Summary:RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1155/2013/804505