Introduction of NDM-1 and OXA-370 from Brazil into Chile in strains of Klebsiella pneumoniae isolated from a single patient

•NDM-1 and OXA-370-producing Klebsiella pneumoniae strains were introduced into Chile from Brazil.•A single patient apparently transmitted a strain to a roommate at a healthcare facility.•K. pneumoniae strains producing NDM-1 and OXA-370 isolated in Chile and Brazil share the same clonal PFGE profil...

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Bibliographic Details
Published in:International journal of infectious diseases 2019-04, Vol.81, p.28-30
Main Authors: Carrasco-Anabalón, Sergio, Conceição Neto, Carlos Orlando, D’Alincourt Carvalho-Assef, Ana Paula, Lima, Celia A., Cifuentes, Marcela, Silva, Francisco, Barrera, Boris, Domínguez, Mariana, González-Rocha, Gerardo, Bello-Toledo, Helia
Format: Article
Language:English
Subjects:
Carbapenemase
Klebsiella pneumoniae
Multi-drug-resistance
NDM-1
OXA-370
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Summary:•NDM-1 and OXA-370-producing Klebsiella pneumoniae strains were introduced into Chile from Brazil.•A single patient apparently transmitted a strain to a roommate at a healthcare facility.•K. pneumoniae strains producing NDM-1 and OXA-370 isolated in Chile and Brazil share the same clonal PFGE profile.•The influence of travel in the spread of resistant microorganisms is demonstrated. Carbapenemase-producing Enterobacteriaceae have rapidly disseminated worldwide and can colonize patients in healthcare centers. As in Chile the first isolations of NDM-1 and OXA-370 carbapenemases were related with a patient arriving from Brazil, the genetic relatedness of Klebsiella pneumoniae strains producers of these enzymes and isolated in both countries was assessed. PFGE analyses revealed that the isolates were clonally related, illustrating how travel contributes to the spread of multidrug-resistant microorganisms. In addition, the occurrence of three different carbapenemases in three different K. pneumoniae strains isolated from a single patient is described.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2019.01.051