Non-integrating episomal vectors induced pluripotent stem cell line (SDPHi001-A) from a healthy female individual

Isolated peripheral blood mononuclear cells (PBMCs) from a healthy female were successfully transformed into induced pluripotent stem cells (iPSCs) by non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-XL. The iPSCs displayed a normal karyotype, expressed pluripotency marke...

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Bibliographic Details
Published in:Stem cell research 2021-10, Vol.56, p.102540-102540, Article 102540
Main Authors: Shao, Jing, Shao, Chunhong, Jin, Yan, Wang, Xiaorui, Fan, Hui, Yang, Guang
Format: Article
Language:English
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Summary:Isolated peripheral blood mononuclear cells (PBMCs) from a healthy female were successfully transformed into induced pluripotent stem cells (iPSCs) by non-integrating episomal vectors containing OCT4, SOX2, c-MYC, KLF4, and BCL-XL. The iPSCs displayed a normal karyotype, expressed pluripotency markers and could differentiate into three germ layers in vitro. This iPSC line may be subsequently used for further researches.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2021.102540