The effect of sham feeding on neurocardiac regulation in healthy human volunteers

Distension and electrical stimuli in the esophagus alter heart rate variability (HRV) consistent with activation of vagal afferent and efferent pathways. Sham feeding stimulates gastric acid secretion by means of vagal efferent pathways. It is not known, however, whether activation of vagal efferent...

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Published in:Canadian journal of gastroenterology 2007-11, Vol.21 (11), p.721-726
Main Authors: Kamath, M V, Spaziani, R, Ullal, S, Tougas, G, Guzman, J C, Morillo, C, Capogna, J, Al-Bayati, Mohammed, Armstrong, David
Format: Article
Language:English
Subjects:
Adult
Eating - physiology
Efferent Pathways - physiology
Electrocardiography
Female
Gastric Acid - metabolism
Heart - innervation
Heart Rate - physiology
Humans
Male
Organ Specificity
Original
Parasympathetic Nervous System - physiology
Placebos
Vagus Nerve - physiology
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Summary:Distension and electrical stimuli in the esophagus alter heart rate variability (HRV) consistent with activation of vagal afferent and efferent pathways. Sham feeding stimulates gastric acid secretion by means of vagal efferent pathways. It is not known, however, whether activation of vagal efferent pathways is organ- or stimulus-specific. To test the hypothesis that sham feeding increases the high frequency (HF) component of HRV, indicating increased neurocardiac vagal activity in association with the known, vagally mediated, increase in gastric acid secretion. Continuous electrocardiography recordings were obtained in 12 healthy, semirecumbent subjects during consecutive 45 min baseline, 20 min sham feeding (standard hamburger meal) and 45 min recovery periods. The R-R intervals and beat-to-beat heart rate signal were determined from digitized electrocardiography recordings; power spectra were computed from the heart rate signal to determine sympathetic (low frequency [LF]) and vagal (HF) components of HRV. Heart rate increased during sham feeding (median 70.8 beats/min, 95% CI 66.0 to 77.6; P
ISSN:0835-7900
DOI:10.1155/2007/891374