Evaluating the therapeutic importance of gold nanoparticles formed by the biogenic synthesis route of Madhuca longifolia reduction

• Published in: Bioresources 2024-02, Vol.19 (1), p.823-841
• Main Authors: Dhayalan, Manikandan, Parveen, Sheikdawood, Thirumalaisamy, Sathiyapriya, Mohammad, Faruq, Al-Lohedan, Hamad A., Riyaz, Savaas Umar Mohammed, Dinesh, Rakshi Anuja, Giri, Jayant, Stalin, Antony, Reddy, Gangireddy Rajasekhar, Anandakumar, Natarajan, Mallik, Saurav
• Format: Article
• Language: English
• Subjects: Anticancer properties; Antimicrobial activity; Antioxidants; Biomedical materials; Bonding strength; Cancer therapies; Cell lines; Chemicals; Chloroauric acid; Colloids; Conformation; E coli; Fourier transforms; Free radicals; Gold; gold nanoparticles; green synthesis; Infrared spectra; Lung cancer; Madhuca longifolia; Micrococcus luteus; Microorganisms; Morphology; mtt assay; Nanomaterials; Nanoparticles; Nanotechnology; Pneumonia; Proteus vulgaris; Salmonella; seed extract; Seeds; Spectrum analysis; Triclosan
• ISSN: 1930-2126; 1930-2126
• DOI: 10.15376/biores.19.1.823-841

Herbal plants have been used, in light of their responsiveness and wide availability, for the construction of a pioneering nanomaterial. In this study, a colloidal suspension of gold nanoparticles (GNPs) was synthesized from an extract of Madhuca longifolia (ML) using chloroauric acid. For biomedical applications, Madhuca longifolia (ML) was used as a bioreductant as well as a capping agent The formed ML-GNPs were analyzed using different analytical techniques, antioxidant assays, and thiazolyl blue formazan assay against A549 cell lines to evaluate clinical relevance. They were further evaluated for their influence on antimicrobial activity using a disc diffusion test against two different microorganisms, Proteus vulgaris and Micrococcus luteus. The ML-GNPs produced had good antioxidant, antibacterial, and anticancer activities. The conformation of the XRD spectra with prominent characteristic planes was indexed to the face-centered cubic (fcc)-structured GNPs. Surface morphology analysis was used to determine the particle size of the GNPs. Fourier transform infrared spectra of the samples were used to determine the analogs for strong H bonding. The MIC values of biogenic GNPs against both strains of Proteus vulgaris and Micrococcus luteus was calculated as 0.29 and 0.96 g/mL, respectively, and triclosan was considered as 0.4 and 2 g/mL, respectively. The findings of this study will be beneficial for future studies of the therapeutic potential of ML-GNPs. Actively, ML-GNPs can be a capable material for formulating nanomedicines after subsequent clinical experiments.