Genetic and functional enrichments associated with Enterococcus faecalis isolated from the urinary tract

Urinary tract infection (UTI) is a global health issue that imposes a substantial burden on healthcare systems. Women are disproportionately affected by UTI, with >60% of women experiencing at least one UTI in their lifetime. UTIs can recur, particularly in postmenopausal women, leading to dimini...

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Published in:mBio 2023-12, Vol.14 (6), p.e0251523
Main Authors: Sharon, Belle M, Arute, Amanda P, Nguyen, Amber, Tiwari, Suman, Reddy Bonthu, Sri Snehita, Hulyalkar, Neha V, Neugent, Michael L, Palacios Araya, Dennise, Dillon, Nicholas A, Zimmern, Philippe E, Palmer, Kelli L, De Nisco, Nicole J
Format: Article
Language:English
Subjects:
adaptation
Enterococcus
genomics
Genomics and Proteomics
host-microbe interactions
hybrid assembly
Research Article
urinary tract infection
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Summary:Urinary tract infection (UTI) is a global health issue that imposes a substantial burden on healthcare systems. Women are disproportionately affected by UTI, with >60% of women experiencing at least one UTI in their lifetime. UTIs can recur, particularly in postmenopausal women, leading to diminished quality of life and potentially life-threatening complications. Understanding how pathogens colonize and survive in the urinary tract is necessary to identify new therapeutic targets that are urgently needed due to rising rates of antimicrobial resistance. How , a bacterium commonly associated with UTI, adapts to the urinary tract remains understudied. Here, we generated a collection of high-quality closed genome assemblies of clinical urinary isolated from the urine of postmenopausal women that we used alongside detailed clinical metadata to perform a robust comparative genomic investigation of genetic factors that may be involved in survival in the urinary tract.
ISSN:2150-7511
2150-7511
DOI:10.1128/mbio.02515-23