Racial differences in comorbidity profile among patients with chronic obstructive pulmonary disease

• Published in: BMC medicine 2018-10, Vol.16 (1), p.178-178, Article 178
• Main Authors: Lee, Hyun, Shin, Sun Hye, Gu, Seonhye, Zhao, Di, Kang, Danbee, Joi, Yeong Rae, Suh, Gee Young, Pastor-Barriuso, Roberto, Guallar, Eliseo, Cho, Juhee, Park, Hye Yun
• Format: Article
• Language: English
• Subjects: Adult; Aged; Analysis; Anemia; Arthritis; Asthma; Biocompatibility; Biomedical materials; Body mass; Body mass index; Body size; Cerebral infarction; Chronic obstructive lung disease; Chronic obstructive pulmonary disease; Comorbidity; COPD; Cross-Sectional Studies; Diabetes mellitus; Dyslipidemia; Ethnicity; Female; Health risk assessment; Humans; Hypertension; Laboratory tests; Lung diseases; Male; Middle Aged; Minority & ethnic groups; Mortality; Myocardial infarction; Nutrition; Nutrition Surveys; Obstructive lung disease; Osteoarthritis; Osteoporosis; Patient outcomes; Patients; Prevalence; Pulmonary Disease, Chronic Obstructive - epidemiology; Quality of Life; Race; Race discrimination; Racial differences; Republic of Korea - epidemiology; Rheumatoid arthritis; Smoking; Social aspects; Stroke; United States
• ISSN: 1741-7015; 1741-7015
• DOI: 10.1186/s12916-018-1159-7

Chronic obstructive pulmonary disease (COPD) is often accompanied by multiple comorbidities, which are associated with an increased risk of exacerbation, a poor health-related quality of life, and high mortality. However, differences in comorbidity profile by race and ethnicity in COPD patients have not been fully elucidated. Participants aged 40 to 79 years with spirometry-defined COPD from the U.S. National Health and Nutrition Examination Survey (NHANES) (2007-2012) and from the Korea NHANES (2007-2015) were analyzed to compare the prevalence of comorbidities by race and ethnicity group. Comorbidities were defined using questionnaire data, physical exams, and laboratory tests. Non-Hispanic Whites had the highest prevalence of dyslipidemia (65.5%), myocardial infarction (6.2%), osteoarthritis (40.1%), and osteoporosis (13.6%), while non-Hispanic Blacks had the highest prevalence of asthma (24.0%), hypertension (70.2%), stroke (7.3%), diabetes mellitus (DM) (23.3%), anemia (16.4%), and rheumatoid arthritis (11.9%). Compared to non-Hispanic Whites, non-Hispanic Blacks had a significantly higher prevalence of hypertension, stroke, DM, anemia, and rheumatoid arthritis after adjusting for age, sex, body mass index, and smoking status, while Hispanics had a significantly higher prevalence of DM and anemia, and Koreans had significantly lower prevalences of all comorbidities except stroke, DM, and anemia. COPD-related comorbidities varied significantly by race and ethnicity, and different strategies may be required for the optimal management of COPD and its comorbidities in different race and ethnicity groups.