Surfactant protein A is decreased in the lung of rats with hepatopulmonary syndrome

PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS...

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Published in:Acta cirúrgica brasileira 2014-09, Vol.29 (9), p.573-578
Main Authors: Nacif, Lucas Souto, Andraus, Wellington, Kubrusly, Márcia Saldanha, Kubrusly, Flávia Saldanha, Gebara, Vera Cristina Bugelli Cainelli, Ishizawa, Andrea, D'Albuquerque, Luiz Augusto Carneiro
Format: Article
Language:English
Subjects:
Hepatopulmonary Syndrome
Models, Animal
Pulmonary Surfactant-Associated Protein A
Rats
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Summary:PURPOSE:To evaluate surfactant protein A levels in an hepatopulmonary syndrome rat model. To date, there have been no studies aimed at evaluating surfactant levels in the setting of cirrhosis or hepatopulmonary syndrome.METHODS:A total of 35 rats were divided into control, sham, and experimental HPS groups. We evaluated surfactant protein A levels in rats and the experimental model designed to induce hepatopulmonary syndrome was common bile duct ligation. Statistical analysis was performed using GraphPad Prism Software(r). Differences were considered statistically significant when p
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-8650201400150004