Human thirst behavior requires transformation of sensory inputs by intrinsic brain networks

To survive and thrive, many animals, including humans, have evolved goal-directed behaviors that can respond to specific physiological needs. An example is thirst, where the physiological need to maintain water balance drives the behavioral basic instinct to drink. Determining the neural basis of su...

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Bibliographic Details
Published in:BMC biology 2022-11, Vol.20 (1), p.255-14, Article 255
Main Authors: Hsu, Li-Ming, Yang, Jen-Tsung, Wen, Xuyun, Liang, Xia, Lin, Leng-Chieh, Huang, Yen-Chu, Tsai, Yuan-Hsiung
Format: Article
Language:English
Subjects:
Animals
Blood
Body composition
Brain
Brain - physiology
Brain mapping
Brain research
Cognition & reasoning
Connectivity analysis
Functional magnetic resonance imaging
Functional MRI
Human acts
Human behavior
Humans
Hydration
Instinct
Intrinsic network
Magnetic Resonance Imaging
Neural circuitry
Neural networks
Osmoregulation
Physiology
Preoptic area
Preoptic area (medial)
Psychological aspects
Thirst
Thirst - physiology
Thirst behavior
Urine
Water
Water balance
Water-electrolyte balance (Physiology)
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Summary:To survive and thrive, many animals, including humans, have evolved goal-directed behaviors that can respond to specific physiological needs. An example is thirst, where the physiological need to maintain water balance drives the behavioral basic instinct to drink. Determining the neural basis of such behaviors, including thirst response, can provide insights into the way brain-wide systems transform sensory inputs into behavioral outputs. However, the neural basis underlying this spontaneous behavior remains unclear. Here, we provide a model of the neural basis of human thirst behavior. We used fMRI, coupled with functional connectivity analysis and serial-multiple mediation analysis, we found that the physiological need for water is first detected by the median preoptic nucleus (MnPO), which then regulates the intention of drinking via serial large-scale spontaneous thought-related intrinsic network interactions that include the default mode network, salience network, and frontal-parietal control network. Our study demonstrates that the transformation in humans of sensory inputs for a single physiological need, such as to maintain water balance, requires large-scale intrinsic brain networks to transform this input into a spontaneous human behavioral response.
ISSN:1741-7007
1741-7007
DOI:10.1186/s12915-022-01446-5