Serum uric acid level in newly diagnosed essential hypertension in a Nepalese population:A hospital based cross sectional study

• Published in: Asian Pacific journal of tropical biomedicine 2014, Vol.4 (1), p.59-64
• Main Authors: Poudel, Bibek, Yadav, Binod Kumar, Kumar, Arun, Jha, Bharat, Raut, Kanak Bahadur
• Format: Article
• Language: English
• Subjects: acid; Adult; Aged; Basic Researches; Committee; Cross-Sectional Studies; diagnosed; Essential Hypertension; Female; Humans; hypertension; Hypertension - blood; Hypertension - epidemiology; Hyperuricemia; Hyperuricemia - blood; Hyperuricemia - epidemiology; Joint; Joint National Committee; Male; Middle Aged; National; Nepal - epidemiology; Newly; Newly diagnosed hypertension; Serum; Serum uric acid; uric; Uric Acid - blood; Young Adult
• ISSN: 2221-1691; 2588-9222
• DOI: 10.1016/S2221-1691(14)60209-4

Objective:To develop the missing link between hyperuricemia and hypertension.Methods:The study was conducted in Department of Biochemistry in collaboration with Nephrology Unit of Internal Medicine Department.Hypertension was defined according to blood pressure readings by definitions of the Seventh Report of the Joint National Committee.Totally 205newly diagnosed and untreated essential hypertensive cases and age-sex matched nonnotensive controls were enrolled in the study.The potential confounding factors of hyperuricemia and hypertension in both cases and controls were controlled.Uric acid levels in all participants were analyzed.Results:Renal function between newly diagnosed hypertensive cases and nonnotensive healthy controls were adjusted.The mean serum uric acid observed in newly diagnosed hypertensive cases and in nonnotensive healthy controls were(290.05±87.03)μmol/L and(245.24±09.38)μmol/L respectively.A total of 59(28.8%)participants of cases and 28(13.7%)participants of controls had hyperuricemia(odds ratio 2.555(95%CI:1.549-4.213),P<0.00l).Conclusions:The mean serum uric acid leveb and number of hyperuricemic subjects were found to be significantly higher in cases when compared to controls.