A First Case Report of Orbital Extra-Adrenal Paraganglioma in Cat

Paraganglioma is a rare neuroendocrine neoplasm originating from paraganglia and consisting of neuroendocrine cells of the sympathetic and parasympathetic nervous system. Extra-adrenal paraganglioma occurs with a low incidence in both humans and animals. This report presents the first case of paraga...

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Bibliographic Details
Published in:Veterinary sciences 2021-05, Vol.8 (5), p.86
Main Authors: Leonardi, Leonardo, Rizac, Raluca Ioana, Pettinari, Ilaria, Mechelli, Luca, De Feo, Carlo
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Binding sites
Biopsy
Body weight
cancer
Case Report
Case reports
cat
Catecholamines
Cytokeratin
Enucleation
extra-adrenal
Hematology
Histopathology
Neoplasia
Nervous system
Neuroendocrine tumors
Neuronal-glial interactions
orbital
Paraganglioma
Parasympathetic nervous system
Phosphopyruvate hydratase
Surgery
Synaptophysin
Tumors
Veterinary medicine
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Summary:Paraganglioma is a rare neuroendocrine neoplasm originating from paraganglia and consisting of neuroendocrine cells of the sympathetic and parasympathetic nervous system. Extra-adrenal paraganglioma occurs with a low incidence in both humans and animals. This report presents the first case of paraganglioma in a cat with orbital primary location. An 18-year-old spayed female European domestic shorthair cat of 3.60 kg body weight was evaluated in a private veterinary clinic in Perugia, Italy, for a pronounced exophthalmos of the right eye. The cat underwent surgery for the enucleation of the right eye and of the mass. The biopsy samples of the removed tissue were fixed in 10% buffered neutral formalin for histological and immunohistochemical evaluations. Therefore, specific markers were used for immunohistochemical investigations, such as anti-neuron specific enolase (NSE), anti-synaptophysin, anti-glial fibrillary acid protein, anti-cytokeratin and anti-chromogranin. The results of these investigations allowed establishing the final diagnosis of ocular extra-adrenal paraganglioma of the cat.
ISSN:2306-7381
2306-7381
DOI:10.3390/vetsci8050086