Interactions of manganese with iron, zinc, and copper in neonatal C57BL/6J and parkin mice following developmental oral manganese exposure

High dose manganese (Mn) exposure can result in changes in tissue concentrations of other essential metals due to Mn-induced alterations in metal absorption and competition for metal transporters and regulatory proteins. We evaluated responses in mice with a Parkin gene defect (parkin mice) and a wi...

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Bibliographic Details
Published in:Data in brief 2017-12, Vol.15, p.908-915
Main Authors: Foster, Melanie L., Bartnikas, Thomas B., Maresca-Fichter, Hailey C., Mercadante, Courtney, Dash, Miriam, Miller, Chelsea, Dorman, David C.
Format: Article
Language:English
Subjects:
Copper
Iron
Manganese Toxicity
Mouse
Neurosciences
Zinc
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Summary:High dose manganese (Mn) exposure can result in changes in tissue concentrations of other essential metals due to Mn-induced alterations in metal absorption and competition for metal transporters and regulatory proteins. We evaluated responses in mice with a Parkin gene defect (parkin mice) and a wildtype strain (C57BL/6J) following neonatal Mn exposure. Neonatal parkin and C57BL/6J littermates were randomly assigned to 0, 11, or 25mg Mn/kg-day dose groups with oral exposures occurring from postnatal day (PND) 1 through PND 28. We report liver, femur, olfactory bulb, striatum, and frontal cortex iron, copper, and zinc concentrations and changes in hepatic gene expression of different metal transporters in PND 29 parkin and C57BL/6J mice. A companion manuscript (Foster et al., 2017) [1] describes the primary study findings. This data provides insights into strain differences in the way Mn interacts with other trace metals in mice.
ISSN:2352-3409
2352-3409
DOI:10.1016/j.dib.2017.10.050