A tissue bandage for pelvic ganglia injury

• Published in: Nature communications 2024-10, Vol.15 (1), p.8972-16, Article 8972
• Main Authors: He, Jing, Qian, Lin, Li, Zhuang, Wang, Yanpeng, Liu, Kai, Wei, Haibin, Sun, Yuan, He, Jiaoyan, Yao, Ke, Weng, Jiahao, Hu, Xuanhan, Zhang, Dahong, He, Yong
• Format: Article
• Language: English
• Subjects: 13/109; 13/31; 13/51; 14/19; 14/28; 14/5; 14/63; 38/91; 631/378/1687; 631/378/1689; 631/378/1959; 631/61/2296; 82/1; 9/10; Animals; Bandages; Bladder; Cell viability; Cytoskeleton; Ganglia; Ganglia - metabolism; Growth factors; Healing; Humanities and Social Sciences; Injuries; Low temperature; Low temperature resistance; Male; Mechanical properties; Medical dressings; Medical materials; multidisciplinary; Pelvic ganglia; Pelvis - injuries; Pelvis - innervation; Quality of life; Rats; Rats, Sprague-Dawley; Resistance factors; Science; Science (multidisciplinary); Stored products; Tight junctions; Tissues; Urinary Bladder - innervation; Urinary Bladder, Neurogenic - etiology; Urinary Bladder, Neurogenic - therapy; Wound healing; Wound Healing - physiology
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-024-53302-5

Neurogenic bladder often occurs after pelvic ganglia injury. Its symptoms, like severe urinary retention and incontinence, have a significant impact on individuals’ quality of life. Unfortunately, there are currently no effective treatments available for this type of injury. Here, we designed a fiber-enhanced tissue bandage for injured pelvic ganglia. Tight junctions formed in tissue bandages create a mini tissue structure that enhances resistance in an in vivo environment and delivers growth factors to support the healing of ganglia. Strength fibers are similar to clinical bandages and guarantee ease of handling. Furthermore, tissue bandages can be stored at low temperatures over 5 months without compromising cell viability, meeting the requirements for clinical products. A tissue bandage was applied to a male rat with a bilateral major pelvic ganglia crush injury. Compared to the severe neurogenic bladder symptoms observed in the injury and scaffold groups, tissue bandages significantly improved bladder function. We found that tissue bandage increases resistance to mechanical injury by boosting the expression of cytoskeletal proteins within the major pelvic ganglia. Overall, tissue bandages show promise as a practical therapeutic approach for ganglia repair, offering hope for developing more effective treatments for this thorny condition. Neurogenic bladder often occurs after pelvic ganglia injury. Here, the authors designed a fiber-enhanced tissue bandage for injured pelvic ganglia that facilitates the delivery of growth factors essential for ganglia healing.