Antibiotic Resistance and Epidemiology of Vibrio parahaemolyticus from Clinical Samples in Nantong, China, 2018-2021

The objective of this study was to investigate the prevalence and molecular characteristics of isolates from fecal samples of patients in Nantong, China. From 2018 to 2021, a total of 106 clinical cases and samples of infection were collected. The virulence genes, serotypes and antibiotic resistance...

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Published in:Infection and drug resistance 2023-01, Vol.16, p.7413-7425
Main Authors: Huang, Ailong, Wang, Yuchao, Xu, Haiyan, Jin, Xiuxiu, Yan, Bingqing, Zhang, Wei
Format: Article
Language:English
Subjects:
Ampicillin
antibiotic resistance
clinical isolates
Drug resistance in microorganisms
Epidemiology
Ethylenediaminetetraacetic acid
Health aspects
Imipenem
Infection
pfge
Seafood
Tetracycline
Tetracyclines
vibrio parahaemolyticus
Virulence (Microbiology)
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Summary:The objective of this study was to investigate the prevalence and molecular characteristics of isolates from fecal samples of patients in Nantong, China. From 2018 to 2021, a total of 106 clinical cases and samples of infection were collected. The virulence genes, serotypes and antibiotic resistance of these isolates were analyzed. Additionally, pulsed-field gel electrophoresis (PFGE) was used to analyze the homogeneity of the isolates. Outbreaks of infection were concentrated in the summer, with seafood consumption being the primary contributing factor, followed by meat and meat products. + + - was confirmed as the most frequently detected virulence genotype among the clinical isolates. 16 serotypes were identified, and O3:K6 was the dominant serotype in Nantong. The antimicrobial susceptibility testing revealed the highest resistance rate to cefazolin (99.1%, 104/106), followed by ampicillin (64.2%, 68/106) and tetracycline (29.2%, 31/106). Fourteen resistant phenotypes were identified, with ampicillin-cefazolin being the most prevalent. The multiple antibiotic resistance (MAR) index ranged from 0.07 to 0.36. PFGE typing clustered isolates with similarity greater than 85% into ten genetic clusters (A-J). Clinical isolates generally exhibited pathogenicity and drug resistance, with some isolates displaying high homology. Clusters C, E, and G were the predominant circulating clusters in this area, posing a potential risk of recurrent outbreaks, which demanded our vigilance.
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S432197