Determination of the phenotypic age in residents of Mexico City: effect of accelerated ageing on lung function and structure

Phenotypic age better represents age-related biological dysregulation than chronological age. Recently, a multisystem-based ageing measure, which integrates chronological age and nine biomarkers, was proposed. Phenotypic age was determined in 774 residents of Mexico City over 60 years old and withou...

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Published in:ERJ open research 2020-07, Vol.6 (3), p.84
Main Authors: Buendía-Roldan, Ivette, Fernández-Plata, Rosario, Valdes-Bartolo, Abigail, Mejia, Mayra, Jaramillo, Luis E, Martínez-Briseño, David, Santiago-Ruiz, Armando, Tapia-Aguilar, Hugo, Gómez-Zamora, Brenda, Pardo, Annie, Selman, Moises
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Language:English
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Summary:Phenotypic age better represents age-related biological dysregulation than chronological age. Recently, a multisystem-based ageing measure, which integrates chronological age and nine biomarkers, was proposed. Phenotypic age was determined in 774 residents of Mexico City over 60 years old and without respiratory problems. We arbitrarily classified as "accelerated" ageing, those showing >4 years compared with their chronological age, and "slowed" ageing, those with
ISSN:2312-0541
2312-0541
DOI:10.1183/23120541.00084-2020