Birth weight, cord blood lipoprotein and apolipoprotein levels in Indian newborns

Primordial prevention of chronic disease is of clinical and public health importance. Considering the fetal onset of atherosclerosis, we aimed to determine the cord blood level of lipoproteins and apolipoproteins as well as their correlation with birth weight and gestational age. This cross-sectiona...

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Bibliographic Details
Published in:International journal of preventive medicine 2010, Vol.1 (1), p.29-33
Main Authors: Kharb, Simmi, Kaur, Ramanjit, Singh, Veena, Sangwan, Krishna
Format: Article
Language:English
Subjects:
Apolipoprotein
Apolipoproteins
Birth weight
Cord blood
Fetal period
Lipoprotein
Lipoproteins
Newborn babies
Original
Preventive medicine
Primordial prevention
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Summary:Primordial prevention of chronic disease is of clinical and public health importance. Considering the fetal onset of atherosclerosis, we aimed to determine the cord blood level of lipoproteins and apolipoproteins as well as their correlation with birth weight and gestational age. This cross-sectional study comprised 100 healthy Indian newborns. Ten ml. of cord blood was collected from placental end of umbilical vein. Serum was separated by centrifugation and analyzed on the same day for lipid profile including total cholesterol (TC), triglycerides (TG), high density lipoprotein- cholesterol (HDL-C), very low density lipoproteincholesterol (VLDL) and low density lipoprotein-cholesterol (LDL-C), apolipoproteins A-I and B (ApoA-I, ApoB). Atherogenic index (AI) was calculated as the ratio of ApoB to ApoA-I. Cord blood of female newborns had higher TC, HDL-C, LDL-C, Apo A-I, Apo B and AI as compared to male newborns, whereas TG and VLDL-C were higher in male than in female newborns. Significant positive correlation was observed between cord blood Apo A-I and HDL-C (r= 0.45, p
ISSN:2008-7802
2008-8213