Identity crisis in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity cris...

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Bibliographic Details
Published in:Pulmonary circulation 2018-01, Vol.8 (1), p.1-5
Main Authors: Ruffenach, G., Bonnet, S., Rousseaux, S., Khochbin, S., Provencher, S., Perros, F.
Format: Article
Language:English
Subjects:
Biochemistry, Molecular Biology
Cancer
cancer hallmarks
Darwinian evolution
Life Sciences
Pulmonary hypertension
Research Letter
tissues‐specific gene
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Summary:Pulmonary arterial hypertension (PAH) shares many hallmarks with cancer. Cancer cells acquire their hallmarks by a pathological Darwinian evolution process built on the so-called cancer cell “identity crisis.” Here we demonstrate that PAH shares the most striking features of the cancer identity crisis: the ectopic expression of normally silent tissue-specific genes.
ISSN:2045-8940
2045-8932
2045-8940
DOI:10.1177/2045893217746054