Hepatitis E virus and neurologic disorders

Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging. During 2004-2009, at 2 hospitals in the United Kingdom and France, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7 (5.5%):...

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Bibliographic Details
Published in:Emerging infectious diseases 2011-02, Vol.17 (2), p.173-179
Main Authors: Kamar, Nassim, Bendall, Richard P, Peron, Jean Marie, Cintas, Pascal, Prudhomme, Laurent, Mansuy, Jean Michel, Rostaing, Lionel, Keane, Frances, Ijaz, Samreen, Izopet, Jacques, Dalton, Harry R
Format: Article
Language:English
Subjects:
Acute Disease
acute hepatitis
Adult
autochthonous
Chronic Disease
chronic hepatitis
CME
Development and progression
Encephalitis
Female
France
Guillain-Barre syndrome
Guillain-Barre Syndrome - physiopathology
Guillain-Barre Syndrome - virology
Health aspects
Hepatitis E
Hepatitis E - complications
Hepatitis E - virology
Hepatitis E virus
Hepatitis E virus - pathogenicity
Humans
Male
Middle Aged
Nervous system diseases
Nervous System Diseases - physiopathology
Nervous System Diseases - virology
neurologic peripheral symptoms
neurologic symptoms
RNA
United Kingdom
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Summary:Information about the spectrum of disease caused by hepatitis E virus (HEV) genotype 3 is emerging. During 2004-2009, at 2 hospitals in the United Kingdom and France, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7 (5.5%): inflammatory polyradiculopathy (n = 3), Guillain-Barre syndrome (n = 1), bilateral brachial neuritis (n = 1), encephalitis (n = 1), and ataxia/proximal myopathy (n = 1). Three cases occurred in nonimmunocompromised patients with acute HEV infection, and 4 were in immunocompromised patients with chronic HEV infection. HEV RNA was detected in cerebrospinal fluid of all 4 patients with chronic HEV infection but not in that of 2 patients with acute HEV infection. Neurologic outcomes were complete resolution (n = 3), improvement with residual neurologic deficit (n = 3), and no improvement (n = 1). Neurologic disorders are an emerging extrahepatic manifestation of HEV infection.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1702.100856