Effects of Immune Cells and Cytokines on Different Cells in OA

The pathological manifestations of osteoarthritis (OA) involve the destruction of articular cartilage, synovial sac thickening, subchondral osteosclerosis and osteophyte formation. The types of cells involved in OA include chondrocytes, osteoblasts, osteoclasts, synovial fibroblasts, T cells, macrop...

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Bibliographic Details
Published in:Journal of inflammation research 2023-01, Vol.16, p.2329-2343
Main Authors: Luo, Pan, Yuan, Qiling, Wan, Xianjie, Yang, Mingyi, Xu, Peng
Format: Article
Language:English
Subjects:
Analysis
chondrocytes
Cytokines
Dendritic cells
immune cells
Lymphocytes
mesenchymal stem cells
Osteoarthritis
osteoblasts
Review
Stem cells
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Summary:The pathological manifestations of osteoarthritis (OA) involve the destruction of articular cartilage, synovial sac thickening, subchondral osteosclerosis and osteophyte formation. The types of cells involved in OA include chondrocytes, osteoblasts, osteoclasts, synovial fibroblasts, T cells, macrophages, and mesenchymal stem cells (MSCs). There are many effects of immune cells in OA, and innate immune cells such as dendritic cells and macrophages have significant roles in the pathogenesis of OA. On the other hand, the role of adaptive immune cells such as T-cell subsets, B-cell subsets, and NK cells is important in OA pathogenesis. MSCs not only play a key role in the dynamic balance and repair of OA tissue but also inhibit the immune system. Therefore, MSCs are a new potential therapeutic agent for OA. This review mainly summarizes the effects of various immune cells and cytokines on different cells in OA to find new effective therapeutic targets for OA therapy based on the immune system and cytokine activity sites to prevent the development of OA.
ISSN:1178-7031
1178-7031
DOI:10.2147/JIR.S413578