Dopamine Concentration Changes Associated with the Retrodialysis of Methylone and 3,4-Methylenedioxypyrovalerone (MDPV) into the Caudate Putamen

Structural modifications to synthetic psychoactive cathinones (SPCs), a class of drugs that contain a β-keto modification of the phenethylamine pharmacophore of amphetamine, induce differences in dopamine transporter (DAT) activity. Here, in vivo retrodialysis was utilized to deliver the SPCs 3,4-me...

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Bibliographic Details
Published in:Brain sciences 2024-03, Vol.14 (3), p.265
Main Authors: Goldsmith, Robert, Aburahma, Amal, Sprague, Jon E
Format: Article
Language:English
Subjects:
Acids
Amphetamines
bath salts
Biomarkers
Brain research
Carbon
Cardiac glycosides
Cardiotonic agents
Catecholamines
cathinone
Caudate-putamen
Cell culture
Cerebrospinal fluid
Chemicals
Dopamine
Dopamine transporter
Drug delivery systems
Ecstasy
Ethylenediaminetetraacetic acid
High performance liquid chromatography
Hydrogels
Laboratory animals
MDPV
methylone
microdialysis
Neurotransmission
Phenethylamine
Phenols
Putamen
Resveratrol
Sampling techniques
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Summary:Structural modifications to synthetic psychoactive cathinones (SPCs), a class of drugs that contain a β-keto modification of the phenethylamine pharmacophore of amphetamine, induce differences in dopamine transporter (DAT) activity. Here, in vivo retrodialysis was utilized to deliver the SPCs 3,4-methylenedioxypyrovalerone (MDPV, a DAT inhibitor) or methylone (a DAT substrate) into the caudate putamen of male Sprague-Dawley rats. Dialysate samples were collected prior to and post drug administration, and temporal changes in dopamine concentration were quantified using HPLC-EC methods. Methylone elicited a 200% increase and MDPV a 470% increase in dopamine levels at the 10 min time point. The findings demonstrate that in vivo retrodialysis can be used to evaluate the effects of SPCs on neurotransmission in the brain.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci14030265