Noni Juice Improves Serum Lipid Profiles and Other Risk Markers in Cigarette Smokers

Cigarette smoke-induced oxidative stress leads to dyslipidemia and systemic inflammation. Morinda citrifolia (noni) fruit juice has been found previously to have a significant antioxidant activity. One hundred thirty-two adult heavy smokers completed a randomized, double blind, placebo-controlled cl...

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Bibliographic Details
Published in:TheScientificWorld 2012-01, Vol.2012 (2012), p.1-8
Main Authors: Wang, Mian-Ying, Peng, Lin, Weidenbacher-Hoper, Vicki, Deng, Shixin, Anderson, Gary, West, Brett J.
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - therapeutic use
Beverages
C-reactive protein
C-Reactive Protein - metabolism
Cholesterol
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cigarette smoke
Clinical Study
Clinical trials
Double-Blind Method
Dyslipidemia
Dyslipidemias - blood
Dyslipidemias - prevention & control
Female
Fruit juices
Fruits
Glycosides
High density lipoprotein
Homocysteine
Homocysteine - blood
Humans
Juices
Lipids - blood
Low density lipoprotein
Male
Morinda - chemistry
Morinda citrifolia
Oxidative stress
Oxidative Stress - drug effects
Phytotherapy
Plant Extracts - therapeutic use
Risk Factors
Smoke
Smoking - blood
Smoking Prevention
Triglycerides
Triglycerides - blood
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Summary:Cigarette smoke-induced oxidative stress leads to dyslipidemia and systemic inflammation. Morinda citrifolia (noni) fruit juice has been found previously to have a significant antioxidant activity. One hundred thirty-two adult heavy smokers completed a randomized, double blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on serum cholesterol, triglyceride, low density lipoprotein cholesterol (LDL), high density lipoprotein cholesterol (HDL), high-sensitivity C-reactive protein (hs-CRP), and homocysteine. Volunteers drank noni juice or a fruit juice placebo daily for one month. Drinking 29.5 mL to 188 mL of noni juice per day significantly reduced cholesterol levels, triglycerides, and hs-CRP. Decreases in LDL and homocysteine, as well increases in HDL, were also observed among noni juice drinkers. The placebo, which was devoid of iridoid glycosides, did not significantly influence blood lipid profiles or hs-CRP. Noni juice was able to mitigate cigarette smoke-induced dyslipidemia, an activity associated with the presence of iridoids.
ISSN:2356-6140
1537-744X
1537-744X
DOI:10.1100/2012/594657