Bioactive Antimicrobial Peptides: A New Weapon to Counteract Zoonosis

Zoonoses have recently become the center of attention of the general population and scientific community. Notably, more than 30 new human pathogens have been identified in the last 30 years, 75% of which can be classified as zoonosis. The complete eradication of such types of infections is far out o...

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Bibliographic Details
Published in:Microorganisms (Basel) 2022-08, Vol.10 (8), p.1591
Main Authors: Zupin, Luisa, Santos-Silva, Carlos André Dos, Al Mughrbi, Aya R Hamad, Vilela, Livia Maria Batista, Benko-Iseppon, Ana Maria, Crovella, Sergio
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial agents
Antimicrobial peptides
antimicrobial treatment
Bioactive compounds
Biological activity
Biomolecules
Control
Coronaviruses
Drug development
Drug resistance
Food contamination & poisoning
Health aspects
infection
Infectious diseases
Low resistance
Microorganisms
Pathogenicity
Pathogens
Peptides
Review
Weapons
Zoonoses
zoonosis
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Summary:Zoonoses have recently become the center of attention of the general population and scientific community. Notably, more than 30 new human pathogens have been identified in the last 30 years, 75% of which can be classified as zoonosis. The complete eradication of such types of infections is far out of reach, considering the limited understanding of animal determinants in zoonoses and their causes of emergence. Therefore, efforts must be doubled in examining the spread, persistence, and pathogenicity of zoonosis and studying possible clinical interventions and antimicrobial drug development. The search for antimicrobial bioactive compounds has assumed great emphasis, considering the emergence of multi-drug-resistant microorganisms. Among the biomolecules of emerging scientific interest are antimicrobial peptides (AMPs), potent biomolecules that can potentially act as important weapons against infectious diseases. Moreover, synthetic AMPs are easily tailored (bioinformatically) to target specific features of the pathogens to hijack, inducing no or very low resistance. Although very promising, previous studies on SAMPs' efficacy are still at their early stages. Indeed, further studies and better characterization on their mechanism of action with in vitro and in vivo assays are needed so as to proceed to their clinical application on human beings.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10081591