A urine-based liquid biopsy for detection of upper tract urothelial carcinoma: a self-matched study

To establish the pathological diagnosis of UTUC before treatment is profitable. At present, the conventional pathological diagnostic methods have certain problems. Besides, the urine-based DNA methylation test have been already utilized to detect bladder cancer. To evaluate the sensitivity and speci...

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Bibliographic Details
Published in:BMC cancer 2024-09, Vol.24 (1), p.1180-9, Article 1180
Main Authors: Wei, Wei, Fan, Panhong, Zhang, Zhishu, Wu, Danting, Liu, Junfeng, Wang, Lingdian, Duan, Xiaoyu, Zhang, Xiaoli, Ding, Degang
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Analysis
Biomarkers, Tumor - urine
Biopsy
Bladder cancer
Carcinoma, Transitional Cell - diagnosis
Carcinoma, Transitional Cell - genetics
Carcinoma, Transitional Cell - pathology
Carcinoma, Transitional Cell - urine
Cellular biology
Cytology
Diagnosis
DNA Methylation
Female
Genes
Hematuria
Humans
Liquid Biopsy - methods
Male
Medical imaging
Methods
Middle Aged
Mutation
Nephrectomy
Nephroureterectomy - methods
p53 Protein
Pathology
Patients
ROC Curve
Sensitivity analysis
Sensitivity and Specificity
Ultrasonic imaging
Upper tract urothelial carcinoma
Ureteroscopy - methods
Urine
Urine sample
Urologic Neoplasms - diagnosis
Urologic Neoplasms - genetics
Urologic Neoplasms - pathology
Urologic Neoplasms - urine
Urothelial carcinoma
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Description
Summary:To establish the pathological diagnosis of UTUC before treatment is profitable. At present, the conventional pathological diagnostic methods have certain problems. Besides, the urine-based DNA methylation test have been already utilized to detect bladder cancer. To evaluate the sensitivity and specificity of DNA methylation plus 17 genes mutation test and compare the combined test with cytology. We included 45 patients from April 2019 to May 2022, all of whom underwent radical nephroureterectomy (RNU), nephrectomy, diagnostic ureteroscopy or tissue biopsy. Before surgery, the urine samples were collected for DNA methylation plus 17 genes mutation test and cytology. The test performance was calculated, and comparative ROC curves were drawn. The median age of the patients was 67 years. The Kappa value of the DNA methylation plus 17 genes mutation test and tissue pathology was 0.59 (p
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-024-12913-3