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A urine-based liquid biopsy for detection of upper tract urothelial carcinoma: a self-matched study
To establish the pathological diagnosis of UTUC before treatment is profitable. At present, the conventional pathological diagnostic methods have certain problems. Besides, the urine-based DNA methylation test have been already utilized to detect bladder cancer. To evaluate the sensitivity and speci...
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| Published in: | BMC cancer 2024-09, Vol.24 (1), p.1180-9, Article 1180 |
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| creator | Wei, Wei Fan, Panhong Zhang, Zhishu Wu, Danting Liu, Junfeng Wang, Lingdian Duan, Xiaoyu Zhang, Xiaoli Ding, Degang |
| description | To establish the pathological diagnosis of UTUC before treatment is profitable. At present, the conventional pathological diagnostic methods have certain problems. Besides, the urine-based DNA methylation test have been already utilized to detect bladder cancer.
To evaluate the sensitivity and specificity of DNA methylation plus 17 genes mutation test and compare the combined test with cytology.
We included 45 patients from April 2019 to May 2022, all of whom underwent radical nephroureterectomy (RNU), nephrectomy, diagnostic ureteroscopy or tissue biopsy. Before surgery, the urine samples were collected for DNA methylation plus 17 genes mutation test and cytology. The test performance was calculated, and comparative ROC curves were drawn.
The median age of the patients was 67 years. The Kappa value of the DNA methylation plus 17 genes mutation test and tissue pathology was 0.59 (p |
| doi_str_mv | 10.1186/s12885-024-12913-3 |
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To evaluate the sensitivity and specificity of DNA methylation plus 17 genes mutation test and compare the combined test with cytology.
We included 45 patients from April 2019 to May 2022, all of whom underwent radical nephroureterectomy (RNU), nephrectomy, diagnostic ureteroscopy or tissue biopsy. Before surgery, the urine samples were collected for DNA methylation plus 17 genes mutation test and cytology. The test performance was calculated, and comparative ROC curves were drawn.
The median age of the patients was 67 years. The Kappa value of the DNA methylation plus 17 genes mutation test and tissue pathology was 0.59 (p<0.001). The sensitivity/specificity/PPV/NPV of DNA methylation plus 17 genes mutation test was 86/80/94/62% compared with 29/100/100/29% for cytology. The AUC of DNA methylation plus 17 genes mutation test was 0.829 (p<0.001).The mutated gene proportion of UTUC patients was 51.43% for TERT and 25.71% for TP53.
The test performance of DNA methylation plus 17 genes mutation test was satisfactory, which may replace cytology in the future. Further multicenter studies with larger samples are needed to confirm the clinical value of this promising method.
We evaluated the diagnostic efficacy of a urine-based liquid biopsy for the detection of UTUC and compared the combined test with cytology. We found satisfactory results and concluded that the test could partly replace cytology. Further studies are needed.</description><identifier>ISSN: 1471-2407</identifier><identifier>EISSN: 1471-2407</identifier><identifier>DOI: 10.1186/s12885-024-12913-3</identifier><identifier>PMID: 39333973</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Analysis ; Biomarkers, Tumor - urine ; Biopsy ; Bladder cancer ; Carcinoma, Transitional Cell - diagnosis ; Carcinoma, Transitional Cell - genetics ; Carcinoma, Transitional Cell - pathology ; Carcinoma, Transitional Cell - urine ; Cellular biology ; Cytology ; Diagnosis ; DNA Methylation ; Female ; Genes ; Hematuria ; Humans ; Liquid Biopsy - methods ; Male ; Medical imaging ; Methods ; Middle Aged ; Mutation ; Nephrectomy ; Nephroureterectomy - methods ; p53 Protein ; Pathology ; Patients ; ROC Curve ; Sensitivity analysis ; Sensitivity and Specificity ; Ultrasonic imaging ; Upper tract urothelial carcinoma ; Ureteroscopy - methods ; Urine ; Urine sample ; Urologic Neoplasms - diagnosis ; Urologic Neoplasms - genetics ; Urologic Neoplasms - pathology ; Urologic Neoplasms - urine ; Urothelial carcinoma</subject><ispartof>BMC cancer, 2024-09, Vol.24 (1), p.1180-9, Article 1180</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>2024. This work is licensed under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c510t-aa3b20953369399ae103eb357a2fac98e505c6b03ce1c81f9a0f302ee557ac4f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438001/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3115124505?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39333973$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Fan, Panhong</creatorcontrib><creatorcontrib>Zhang, Zhishu</creatorcontrib><creatorcontrib>Wu, Danting</creatorcontrib><creatorcontrib>Liu, Junfeng</creatorcontrib><creatorcontrib>Wang, Lingdian</creatorcontrib><creatorcontrib>Duan, Xiaoyu</creatorcontrib><creatorcontrib>Zhang, Xiaoli</creatorcontrib><creatorcontrib>Ding, Degang</creatorcontrib><title>A urine-based liquid biopsy for detection of upper tract urothelial carcinoma: a self-matched study</title><title>BMC cancer</title><addtitle>BMC Cancer</addtitle><description>To establish the pathological diagnosis of UTUC before treatment is profitable. At present, the conventional pathological diagnostic methods have certain problems. Besides, the urine-based DNA methylation test have been already utilized to detect bladder cancer.
To evaluate the sensitivity and specificity of DNA methylation plus 17 genes mutation test and compare the combined test with cytology.
We included 45 patients from April 2019 to May 2022, all of whom underwent radical nephroureterectomy (RNU), nephrectomy, diagnostic ureteroscopy or tissue biopsy. Before surgery, the urine samples were collected for DNA methylation plus 17 genes mutation test and cytology. The test performance was calculated, and comparative ROC curves were drawn.
The median age of the patients was 67 years. The Kappa value of the DNA methylation plus 17 genes mutation test and tissue pathology was 0.59 (p<0.001). The sensitivity/specificity/PPV/NPV of DNA methylation plus 17 genes mutation test was 86/80/94/62% compared with 29/100/100/29% for cytology. The AUC of DNA methylation plus 17 genes mutation test was 0.829 (p<0.001).The mutated gene proportion of UTUC patients was 51.43% for TERT and 25.71% for TP53.
The test performance of DNA methylation plus 17 genes mutation test was satisfactory, which may replace cytology in the future. Further multicenter studies with larger samples are needed to confirm the clinical value of this promising method.
We evaluated the diagnostic efficacy of a urine-based liquid biopsy for the detection of UTUC and compared the combined test with cytology. We found satisfactory results and concluded that the test could partly replace cytology. Further studies are needed.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biomarkers, Tumor - urine</subject><subject>Biopsy</subject><subject>Bladder cancer</subject><subject>Carcinoma, Transitional Cell - diagnosis</subject><subject>Carcinoma, Transitional Cell - genetics</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Carcinoma, Transitional Cell - urine</subject><subject>Cellular biology</subject><subject>Cytology</subject><subject>Diagnosis</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Genes</subject><subject>Hematuria</subject><subject>Humans</subject><subject>Liquid Biopsy - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Nephrectomy</subject><subject>Nephroureterectomy - methods</subject><subject>p53 Protein</subject><subject>Pathology</subject><subject>Patients</subject><subject>ROC Curve</subject><subject>Sensitivity analysis</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonic imaging</subject><subject>Upper tract urothelial carcinoma</subject><subject>Ureteroscopy - methods</subject><subject>Urine</subject><subject>Urine sample</subject><subject>Urologic Neoplasms - diagnosis</subject><subject>Urologic Neoplasms - genetics</subject><subject>Urologic Neoplasms - pathology</subject><subject>Urologic Neoplasms - urine</subject><subject>Urothelial carcinoma</subject><issn>1471-2407</issn><issn>1471-2407</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptktuL1DAUxoso7rr6D_ggAUH0oWsuvcUXGRYvAwuCl-dwmp7MZGib2SQV57833VnXqUgeGk5_3wfny5dlzxm9ZKyp3gbGm6bMKS9yxiUTuXiQnbOiZjkvaP3w5H6WPQlhRymrG9o8zs6EFELIWpxnekUmb0fMWwjYkd7eTLYjrXX7cCDGedJhRB2tG4kzZNrv0ZPoQcckc3GLvYWeaPDajm6AdwRIwN7kA0S9TX4hTt3hafbIQB_w2d33Ivvx8cP3q8_59ZdP66vVda5LRmMOIFpOZSlEJYWUgIwKbEVZAzegZYMlLXXVUqGR6YYZCdQIyhHLhOjCiItsffTtHOzU3tsB_EE5sOp24PxGgY9W96gYIi2MKbiuugKquq3aTtI0A62laGXyen_02k_tgJ3GMW3dL0yXf0a7VRv3UzFWiCYlnRxe3zl4dzNhiGqwQWPfw4huCkowRiWt6lok9OU_6M5NfkxZzVTJeJFW_0ttIG1gR-Pmh5hN1aphtKC8rnmiLv9DpdPhYLUb0dg0XwjeLASJifgrbmAKQa2_fV2yr07YLUIft8H109yPsAT5EdTeheDR3CfHqJrLq47lVam86ra8ao7hxWnm95I_bRW_ARAG58A</recordid><startdate>20240927</startdate><enddate>20240927</enddate><creator>Wei, Wei</creator><creator>Fan, Panhong</creator><creator>Zhang, Zhishu</creator><creator>Wu, Danting</creator><creator>Liu, Junfeng</creator><creator>Wang, Lingdian</creator><creator>Duan, Xiaoyu</creator><creator>Zhang, Xiaoli</creator><creator>Ding, Degang</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240927</creationdate><title>A urine-based liquid biopsy for detection of upper tract urothelial carcinoma: a self-matched study</title><author>Wei, Wei ; Fan, Panhong ; Zhang, Zhishu ; Wu, Danting ; Liu, Junfeng ; Wang, Lingdian ; Duan, Xiaoyu ; Zhang, Xiaoli ; Ding, Degang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-aa3b20953369399ae103eb357a2fac98e505c6b03ce1c81f9a0f302ee557ac4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biomarkers, Tumor - urine</topic><topic>Biopsy</topic><topic>Bladder cancer</topic><topic>Carcinoma, Transitional Cell - diagnosis</topic><topic>Carcinoma, Transitional Cell - genetics</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Carcinoma, Transitional Cell - urine</topic><topic>Cellular biology</topic><topic>Cytology</topic><topic>Diagnosis</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Genes</topic><topic>Hematuria</topic><topic>Humans</topic><topic>Liquid Biopsy - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Nephrectomy</topic><topic>Nephroureterectomy - methods</topic><topic>p53 Protein</topic><topic>Pathology</topic><topic>Patients</topic><topic>ROC Curve</topic><topic>Sensitivity analysis</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonic imaging</topic><topic>Upper tract urothelial carcinoma</topic><topic>Ureteroscopy - methods</topic><topic>Urine</topic><topic>Urine sample</topic><topic>Urologic Neoplasms - diagnosis</topic><topic>Urologic Neoplasms - genetics</topic><topic>Urologic Neoplasms - pathology</topic><topic>Urologic Neoplasms - urine</topic><topic>Urothelial carcinoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Wei</creatorcontrib><creatorcontrib>Fan, Panhong</creatorcontrib><creatorcontrib>Zhang, Zhishu</creatorcontrib><creatorcontrib>Wu, Danting</creatorcontrib><creatorcontrib>Liu, Junfeng</creatorcontrib><creatorcontrib>Wang, Lingdian</creatorcontrib><creatorcontrib>Duan, Xiaoyu</creatorcontrib><creatorcontrib>Zhang, Xiaoli</creatorcontrib><creatorcontrib>Ding, Degang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>BMC cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Wei</au><au>Fan, Panhong</au><au>Zhang, Zhishu</au><au>Wu, Danting</au><au>Liu, Junfeng</au><au>Wang, Lingdian</au><au>Duan, Xiaoyu</au><au>Zhang, Xiaoli</au><au>Ding, Degang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A urine-based liquid biopsy for detection of upper tract urothelial carcinoma: a self-matched study</atitle><jtitle>BMC cancer</jtitle><addtitle>BMC Cancer</addtitle><date>2024-09-27</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>1180</spage><epage>9</epage><pages>1180-9</pages><artnum>1180</artnum><issn>1471-2407</issn><eissn>1471-2407</eissn><abstract>To establish the pathological diagnosis of UTUC before treatment is profitable. At present, the conventional pathological diagnostic methods have certain problems. Besides, the urine-based DNA methylation test have been already utilized to detect bladder cancer.
To evaluate the sensitivity and specificity of DNA methylation plus 17 genes mutation test and compare the combined test with cytology.
We included 45 patients from April 2019 to May 2022, all of whom underwent radical nephroureterectomy (RNU), nephrectomy, diagnostic ureteroscopy or tissue biopsy. Before surgery, the urine samples were collected for DNA methylation plus 17 genes mutation test and cytology. The test performance was calculated, and comparative ROC curves were drawn.
The median age of the patients was 67 years. The Kappa value of the DNA methylation plus 17 genes mutation test and tissue pathology was 0.59 (p<0.001). The sensitivity/specificity/PPV/NPV of DNA methylation plus 17 genes mutation test was 86/80/94/62% compared with 29/100/100/29% for cytology. The AUC of DNA methylation plus 17 genes mutation test was 0.829 (p<0.001).The mutated gene proportion of UTUC patients was 51.43% for TERT and 25.71% for TP53.
The test performance of DNA methylation plus 17 genes mutation test was satisfactory, which may replace cytology in the future. Further multicenter studies with larger samples are needed to confirm the clinical value of this promising method.
We evaluated the diagnostic efficacy of a urine-based liquid biopsy for the detection of UTUC and compared the combined test with cytology. We found satisfactory results and concluded that the test could partly replace cytology. Further studies are needed.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39333973</pmid><doi>10.1186/s12885-024-12913-3</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC cancer, 2024-09, Vol.24 (1), p.1180-9, Article 1180 |
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| subjects | Aged Aged, 80 and over Analysis Biomarkers, Tumor - urine Biopsy Bladder cancer Carcinoma, Transitional Cell - diagnosis Carcinoma, Transitional Cell - genetics Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - urine Cellular biology Cytology Diagnosis DNA Methylation Female Genes Hematuria Humans Liquid Biopsy - methods Male Medical imaging Methods Middle Aged Mutation Nephrectomy Nephroureterectomy - methods p53 Protein Pathology Patients ROC Curve Sensitivity analysis Sensitivity and Specificity Ultrasonic imaging Upper tract urothelial carcinoma Ureteroscopy - methods Urine Urine sample Urologic Neoplasms - diagnosis Urologic Neoplasms - genetics Urologic Neoplasms - pathology Urologic Neoplasms - urine Urothelial carcinoma |
| title | A urine-based liquid biopsy for detection of upper tract urothelial carcinoma: a self-matched study |
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