Outcome analysis of breast cancer patients who declined evidence-based treatment

To analyze the characteristics and outcomes of women with breast cancer in the Northern Alberta Health Region (NAHR) who declined recommended primary standard treatments. A chart review was performed of breast cancer patients who refused recommended treatments during the period 1980 to 2006. A match...

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Bibliographic Details
Published in:World journal of surgical oncology 2012-06, Vol.10 (1), p.118-118, Article 118
Main Authors: Joseph, Kurian, Vrouwe, Sebastian, Kamruzzaman, Anmmd, Balbaid, Ali, Fenton, David, Berendt, Richard, Yu, Edward, Tai, Patricia
Format: Article
Language:English
Subjects:
Adult
Aged
Alternative medicine
Analysis
Breast cancer
Breast Neoplasms - drug therapy
Breast Neoplasms - mortality
Cancer patients
Cancer therapies
Care and treatment
Chemotherapy
Complementary Therapies
Confidence Intervals
Decision making
Evidence-Based Medicine
Female
Health aspects
Humans
Incidence
Middle Aged
Patient outcomes
Prognosis
Retrospective Studies
Treatment Outcome
Treatment Refusal
Women's Health
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Summary:To analyze the characteristics and outcomes of women with breast cancer in the Northern Alberta Health Region (NAHR) who declined recommended primary standard treatments. A chart review was performed of breast cancer patients who refused recommended treatments during the period 1980 to 2006. A matched pair analysis was performed to compare the survival data between those who refused or received standard treatments. A total of 185 (1.2%) patients refused standard treatment. Eighty-seven (47%) were below the age of 75 at diagnosis. The majority of those who refused standard treatments were married (50.6%), 50 years or older (60.9%), and from the urban area (65.5%). The 5-year overall survival rates were 43.2% (95% CI: 32.0 to 54.4%) for those who refused standard treatments and 81.9% (95% CI: 76.9 to 86.9%) for those who received them. The corresponding values for the disease-specific survival were 46.2% (95% CI: 34.9 to 57.6%) vs. 84.7% (95% CI: 80.0 to 89.4%). Women who declined primary standard treatment had significantly worse survival than those who received standard treatments. There is no evidence to support using Complementary and Alternative Medicine (CAM) as primary cancer treatment.
ISSN:1477-7819
1477-7819
DOI:10.1186/1477-7819-10-118