Spinal cord organoids add an extra dimension to traditional motor neuron cultures

Because of these unique properties, neural organoids have been used extensively to study diseases associated with neurodevelopment and neurodegeneration. [...]3D cell cultures were able to recapitulate extracellular amyloid aggregation, and demonstrate an accumulation of hyperphosphorylated tau prot...

Full description

Saved in:
Bibliographic Details
Published in:Neural regeneration research 2019-09, Vol.14 (9), p.1515-1516
Main Authors: Khong, Zi-Jian, Hor, Jin-Hui, Ng, Shi-Yan
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Brain
Cells (Biology)
Disease
Microcephaly
Motor neurons
Neurodegeneration
Neurons
Neurophysiology
Pathogenesis
Physiological aspects
Spinal cord
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Because of these unique properties, neural organoids have been used extensively to study diseases associated with neurodevelopment and neurodegeneration. [...]3D cell cultures were able to recapitulate extracellular amyloid aggregation, and demonstrate an accumulation of hyperphosphorylated tau proteins and higher neuronal apoptosis rates in Alzheimer’s disease cerebral organoids (Choi et al., 2014), modeling the neurodegeneration phenotype. [...]brain organoids are of immense interest for modeling human neurodevelopment and neurodegeneration because of their ability to recapitulate fundamental pathogenic features and mechanisms. [...]these organoids were patterned along the rostrocaudal axis, where we observed HOXB4+ brachial and HOXC8+ thoracic spinal cell type, in the absence of exogenous GDF11. [...]single cell technologies together with our ventral spinal cord organoids will help to shed light on cell type specification, diversity and disease-specific programs in our ventral spinal cord organoids.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.255966