Oligodendroglial primary cilium heterogeneity during development and demyelination/remyelination

The primary cilium (PC) has emerged as an indispensable cellular antenna essential for signal transduction of important cell signaling pathways. The rapid acquisition of knowledge about PC biology has raised attention to PC as a therapeutic target in some neurological and psychiatric diseases. Howev...

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Published in:Frontiers in cellular neuroscience 2022-11, Vol.16, p.1049468-1049468
Main Authors: Delfino, Giada, Bénardais, Karelle, Graff, Julien, Samama, Brigitte, Antal, Maria Cristina, Ghandour, M Said, Boehm, Nelly
Format: Article
Language:English
Subjects:
Ablation
Animals
Antibodies
Cell culture
Cell differentiation
Cell proliferation
Central nervous system
Chloral hydrate
demyelinating diseases
Demyelination
development
Forskolin
Glial stem cells
Laboratories
Lithium
Lithium chloride
Localization
Mental disorders
Myelination
Neuroscience
Oligodendrocytes
OPCs
primary cilium
Signal transduction
Therapeutic targets
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Summary:The primary cilium (PC) has emerged as an indispensable cellular antenna essential for signal transduction of important cell signaling pathways. The rapid acquisition of knowledge about PC biology has raised attention to PC as a therapeutic target in some neurological and psychiatric diseases. However, the role of PC in oligodendrocytes and its participation in myelination/remyelination remain poorly understood. Oligodendrocyte precursor cells (OPCs) give rise to oligodendrocytes during central nervous system (CNS) development. In adult, a small percentage of OPCs remains as undifferentiated cells located sparsely in the different regions of the CNS. These cells can regenerate oligodendrocytes and participate to certain extent in remyelination. This study aims characterize PC in oligodendrocyte lineage cells during post-natal development and in a mouse model of demyelination/remyelination. We show heterogeneity in the frequency of cilium presence on OPCs, depending on culture conditions and cerebral regions during development and demyelination/remyelination. , Lithium chloride (LiCl), Forskolin and Chloral Hydrate differentially affect cilium, depending on culture environment and PC length correlates with the cell differentiation state. Beside the role of PC as a keeper of cell proliferation, our results suggest its involvement in myelination/remyelination.
ISSN:1662-5102
1662-5102
DOI:10.3389/fncel.2022.1049468