Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

This study evaluated the gastroprotective value of the methanol extracts from fruits of Morus nigra L. (black mulberry (MEMN)) and Rubus niveus Thunb (raspberry (MERN)). The total phenolic compounds and flavonoids were measured, as well as the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radic...

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Published in:Gastroenterology research and practice 2017-01, Vol.2017 (2017), p.1-8
Main Authors: da Silva, Luisa Mota, Faloni de Andrade, Sérgio, Campos, Adriana, de Souza, Priscila, Mariano, Luísa Nathália Bolda, Mariot, Marihá, Beleza, Maria Luisa Maes Lima, Nesello, Luciane Angela Nottar, Cechinel Filho, Valdir
Format: Article
Language:English
Subjects:
Alcohol
Animals
Antioxidants
Archives & records
Berries
Blackberries
Care and treatment
Ethanol
Flavonoids
Free radicals
Gastroenterology
Health aspects
Infections
Methanol
Mulberry
Nonsteroidal anti-inflammatory drugs
Polyphenols
Stomach ulcer
Ulcers
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Summary:This study evaluated the gastroprotective value of the methanol extracts from fruits of Morus nigra L. (black mulberry (MEMN)) and Rubus niveus Thunb (raspberry (MERN)). The total phenolic compounds and flavonoids were measured, as well as the in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenger activity. The gastroprotective effects of the extracts against 60% ethanol/0.3 M HCl were evaluated in mice. After that, the lipid hydroperoxides and reduced glutathione levels at ulcerated tissue were determined. The effects of extracts on H+/K+-ATPase activity were also verified. The extracts exhibited high contents of polyphenols; however, MERN presented 1.5-fold higher levels. The presence of flavonoids also was confirmed. In addition, MEMN (IC50 = 13.74 μg/mL) and MERN (IC50 = 14.97 μg/mL) scavenged DPPH radical. The MEMN reduced the ulcer area only at 300 mg/kg (p.o.) by 64.06%. Interestingly, MERN decreased the ulcer area in a superior potency (ED50 = 20.88 mg/kg), reducing the ulcer area by 81.86% at 300 mg/kg, and increased the gastric mucin levels. The antioxidant effects of extracts were evidenced by reduced lipoperoxides and increased reduction of glutathione amount in the gastric mucosa. However, MEMN or MERN did not change the H+/K+-ATPase activity. These results confirm that M. nigra and R. niveus are berries with a gastroprotective value by strengthening of gastric protective factors.
ISSN:1687-6121
1687-630X
DOI:10.1155/2017/7089697