Dexmedetomidine Protects against Airway Inflammation and Airway Remodeling in a Murine Model of Chronic Asthma through TLR4/NF-κB Signaling Pathway

Asthma is a common respiratory disease characterized by chronic airway inflammation. Dexmedetomidine (DEX), a highly selective α2 adrenergic receptor agonist, has been shown to participate in regulating inflammatory states and thus exert organ protective actions. However, the potential of DEX in ast...

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Published in:Mediators of inflammation 2023-02, Vol.2023, p.3695469-11
Main Authors: Zhou, Ying, Du, Xiyu, Wang, Qianyu, Xiao, Shilin, Zhi, Juan, Gao, Huibin, Yang, Dong
Format: Article
Language:English
Subjects:
Adaptor proteins
Adrenergic receptors
Animal models
Anti-inflammatory agents
Antibodies
Asthma
Dexamethasone
Dexmedetomidine
Inflammation
Laboratory animals
Lungs
Medical research
NF-κB protein
Ostomy
Proteins
Respiratory diseases
Respiratory tract
Respiratory tract diseases
Scientific equipment and supplies industry
Signal transduction
Steroids
TLR4 protein
Toll-like receptors
Yohimbine
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container_title Mediators of inflammation
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creator Zhou, Ying
Du, Xiyu
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description Asthma is a common respiratory disease characterized by chronic airway inflammation. Dexmedetomidine (DEX), a highly selective α2 adrenergic receptor agonist, has been shown to participate in regulating inflammatory states and thus exert organ protective actions. However, the potential of DEX in asthma is still unknown. This study is aimed at investigating the role of DEX in a mouse model of house dust mite- (HDM-) induced asthma and exploring its underlying mechanism. Here, we found that DEX treatment significantly ameliorated airway hyperresponsiveness, airway inflammation, and airway remodeling in the asthmatic mice, which were similar to the efficacy of the reference anti-inflammatory drug dexamethasone. In addition, DEX reversed the increased expression of toll-like receptor 4 (TLR4) and its downstream signaling adaptor molecule nuclear factor-κB (NF-κB) in the lung tissue of asthmatic mice. Furthermore, these protective effects of DEX were abolished by yohimbine, an α2 adrenergic receptor antagonist. These results indicate that DEX is capable of ameliorating airway inflammation and remodeling in asthmatic mice, and this protective effect is associated with the inhibition of the TLR4/NF-κB signaling pathway.
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subjects Adaptor proteins
Adrenergic receptors
Animal models
Anti-inflammatory agents
Antibodies
Asthma
Dexamethasone
Dexmedetomidine
Inflammation
Laboratory animals
Lungs
Medical research
NF-κB protein
Ostomy
Proteins
Respiratory diseases
Respiratory tract
Respiratory tract diseases
Scientific equipment and supplies industry
Signal transduction
Steroids
TLR4 protein
Toll-like receptors
Yohimbine
title Dexmedetomidine Protects against Airway Inflammation and Airway Remodeling in a Murine Model of Chronic Asthma through TLR4/NF-κB Signaling Pathway
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