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Increased serum activin A level in congenital heart disease-associated pulmonary artery hypertension: A comparative study from the COHARD-PH registry

Activin A, a member of TGF-β superfamily, has been implicated in the pathogenesis of pulmonary artery hypertension (PAH). PAH due to congenital heart disease (CHD-PAH) is a major problem in developing countries. Activin A may have a role in PAH development and progression among uncorrected CHD. In t...

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Bibliographic Details
Published in:Pulmonary circulation 2023-07, Vol.13 (3), p.e12280-e12280
Main Authors: Hadwiono, Muhammad R, Hartopo, Anggoro B, Wasityastuti, Widya, Anggrahini, Dyah W, Ryanto, Gusty R T, Emoto, Noriaki, Dinarti, Lucia K
Format: Article
Language:English
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Summary:Activin A, a member of TGF-β superfamily, has been implicated in the pathogenesis of pulmonary artery hypertension (PAH). PAH due to congenital heart disease (CHD-PAH) is a major problem in developing countries. Activin A may have a role in PAH development and progression among uncorrected CHD. In this comparative study, serum activin A level was significantly increased in subjects with uncorrected CHD without the presence of PH and were more significantly risen in CHD-PAH, as compared to control. The utilization of serum activin A measurement seems promising to identify uncorrected CHD patients with PAH development and progression.
ISSN:2045-8932
2045-8940
2045-8940
DOI:10.1002/pul2.12280