The additive effects of kidney dysfunction on left ventricular function and strain in type 2 diabetes mellitus patients verified by cardiac magnetic resonance imaging

Patients with type 2 diabetes mellitus (T2DM) are susceptible to coexisted with chronic kidney disease (CKD), which may increase cardiovascular mortality in these patients. The present study aimed to verify whether CKD aggravates the deterioration of left ventricular (LV) myocardial strain in T2DM p...

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Bibliographic Details
Published in:Cardiovascular diabetology 2021-01, Vol.20 (1), p.11-11, Article 11
Main Authors: Zhang, Yi, Wang, Jin, Ren, Yan, Yan, Wei-Feng, Jiang, Li, Li, Yuan, Yang, Zhi-Gang
Format: Article
Language:English
Subjects:
Age
Blood pressure
Body mass index
Cardiac function
Cardiovascular diseases
Chronic kidney disease
Creatinine
Diabetes
Diabetes mellitus (non-insulin dependent)
Disease
Electrocardiography
Epidermal growth factor receptors
Gender
Glomerular filtration rate
Glucose
Heart
Heart rate
Hypertension
Kidney diseases
Left ventricular
Magnetic resonance imaging
Mortality
Normal distribution
Original Investigation
Patients
Risk factors
Software
Strain
Triglycerides
Type 2 diabetes mellitus
Uric acid
Ventricle
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Summary:Patients with type 2 diabetes mellitus (T2DM) are susceptible to coexisted with chronic kidney disease (CKD), which may increase cardiovascular mortality in these patients. The present study aimed to verify whether CKD aggravates the deterioration of left ventricular (LV) myocardial strain in T2DM patients and to explore the risk factors associated with LV strain. In total, 105 T2DM patients and 52 healthy individuals were included and underwent cardiac magnetic resonance examination. Patients were divided into the following two groups: T2DM with CKD (n = 33) and T2DM without CKD (n = 72). The baseline clinical and biochemical indices were obtained from hospital records before the cardiac magnetic resonance scan. Cine sequences, including long-axis views (2-chamber and 4-chamber) and short-axis views, were acquired. LV function and global strain parameters were measured based on cine sequences and compared among three groups. Pearson's analysis was performed to investigate the correlation between LV strain parameters and clinical indices. Multiple linear regression analysis was used to identify the independent indicators of LV strain. Compared with normal controls, T2DM patients without CKD had a significantly decreased magnitude of peak strain (PS; radial), peak systolic strain rate (radial), and peak diastolic strain rate (radial and circumferential) (all P 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-020-01203-4