Stearoyl-CoA Desaturase 1 as a Therapeutic Biomarker: Focusing on Cancer Stem Cells

The dysregulation of lipid metabolism and alterations in the ratio of monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) have been implicated in cancer progression and stemness. Stearoyl-CoA desaturase 1 (SCD1), an enzyme involved in lipid desaturation, is crucial in regulating this...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (10), p.8951
Main Authors: Min, Jin-Young, Kim, Do-Hee
Format: Article
Language:English
Subjects:
Autophagy
Biomarkers
Biosynthesis
Cancer
cancer progression
cancer stem cells
Cancer therapies
Cell division
Cell growth
Cell self-renewal
Cell Survival
Colorectal cancer
Desaturase
Desaturation
Development and progression
Energy
Enzymes
Fatty acids
Fatty Acids - metabolism
Fatty Acids, Monounsaturated - metabolism
Fluidity
Gene expression
Health aspects
Kinases
Lipid metabolism
Lipids
Liver cancer
Lung cancer
Malignancy
Membrane fluidity
Membranes
Metabolism
Monounsaturated fatty acids
Natural products
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplastic Stem Cells - metabolism
Oxidation
phytochemicals
Proteins
Review
Saturated fatty acids
SCD1
Signal transduction
Stearoyl-CoA desaturase
Stearoyl-CoA Desaturase - metabolism
Stem cells
Survival
Tumorigenesis
Tumors
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Summary:The dysregulation of lipid metabolism and alterations in the ratio of monounsaturated fatty acids (MUFAs) to saturated fatty acids (SFAs) have been implicated in cancer progression and stemness. Stearoyl-CoA desaturase 1 (SCD1), an enzyme involved in lipid desaturation, is crucial in regulating this ratio and has been identified as an important regulator of cancer cell survival and progression. SCD1 converts SFAs into MUFAs and is important for maintaining membrane fluidity, cellular signaling, and gene expression. Many malignancies, including cancer stem cells, have been reported to exhibit high expression of SCD1. Therefore, targeting SCD1 may provide a novel therapeutic strategy for cancer treatment. In addition, the involvement of SCD1 in cancer stem cells has been observed in various types of cancer. Some natural products have the potential to inhibit SCD1 expression/activity, thereby suppressing cancer cell survival and self-renewal activity.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24108951