Hybrid Lipid/Clay Carrier Systems Containing Annatto Oil for Topical Formulations

• Published in: Pharmaceutics 2022-05, Vol.14 (5), p.1067
• Main Authors: Barbosa, Raquel de Melo, Leite, Aliana Monteiro, García-Villén, Fátima, Sánchez-Espejo, Rita, Cerezo, Pilar, Viseras, César, Faccendini, Angela, Sandri, Giuseppina, Raffin, Fernanda Nervo, Moura, Túlio Flávio Accioly de Lima E
• Format: Article
• Language: English
• Subjects: Bixa orellana L; Chemical properties; Clay; colloidal suspension; Dosage and administration; Drug resistance; Essences and essential oils; Fibroblasts; Heat resistance; hybrid system; Hydrogels; Lipids; Medicinal plants; Nanocomposites; Nanomedicine; Nanoparticles; Particle size; topical formulations; Transdermal medication; Ulcers; Wound healing
• ISSN: 1999-4923; 1999-4923
• DOI: 10.3390/pharmaceutics14051067

Nanocomposites formed by clay and lipid carriers (NLCs) show a high potential for providing controlled release and specific delivery of bioactive molecules and have recently gained attention in the pharmaceutical sector due to their ability to transport hydrophilic and hydrophobic drugs. Recent studies have recognized the biological activity of the oil of Bixa orellana L. (AO) with regards to its healing, antioxidant, antibacterial, and anti-leishmanial properties. Therefore, the purpose of this study is the preparation and characterization of hybrid systems based on lipid nanocarriers and laponite for the delivery of AO. NLCs were prepared by the fusion-emulsification method, using cetyl palmitate (CP) or myristyl myristate (MM), AO, and Poloxamer 188. The morphology, hydrodynamic diameters, zeta potential (ZP), polydispersity index (PDI), thermal analysis, X-ray diffraction analysis (XRD), viscosity behavior, and cytotoxicity testing of the hybrid systems were performed. The thermal study and X-ray diffraction analyses (XRD) revealed polymorphic structural changes compatible with the amorphization of the material. Rheological assays highlighted a typical pseudoplastic behavior in all systems (MM and CP with LAP). The hybrid systems’ morphology, size diameters, and PDIs were similar, preset spherical and monodisperse structures (≈200 nm;