Antimicrobial, Antibiofilm and Toxicological Assessment of Propolis

Antimicrobial resistance is a serious problem for the control of infections and infectious diseases. Propolis is a substance produced by honeybees with antimicrobial and antibiofilm properties. To consider propolis as an alternative to the use of antimicrobials for infection control, we assessed its...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-02, Vol.12 (2), p.347
Main Authors: Queiroga, Maria Cristina, Laranjo, Marta, Andrade, Nara, Marques, Mariana, Costa, Ana Rodrigues, Antunes, Célia Maria
Format: Article
Language:English
Subjects:
Analysis
Antibacterial agents
antibiofilm
antimicrobial
Antimicrobial activity
Antimicrobial agents
Antimicrobial resistance
Bacteria
Bees
Biocompatibility
Biofilms
Connective tissues
Drug resistance
Drug resistance in microorganisms
Epithelial cells
Epithelium
Evaluation
fibroblast
Fibroblasts
Flavonoids
Health aspects
Health services
Honeybee
Infection
Infections
Infectious diseases
Kaempferol
Keratinocytes
Medical research
Medicine, Experimental
Propolis
Staphylococcal infections
Staphylococcus
Staphylococcus infections
Toxicity
Toxicity testing
toxicological
Veterinary medicine
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Summary:Antimicrobial resistance is a serious problem for the control of infections and infectious diseases. Propolis is a substance produced by honeybees with antimicrobial and antibiofilm properties. To consider propolis as an alternative to the use of antimicrobials for infection control, we assessed its antimicrobial and antibiofilm activities. To assess propolis for topical medical use, toxicological studies were also performed. A Portuguese 70% propolis ethanolic extract was chemically evaluated and studied for antimicrobial activity on staphylococcal field isolates (n = 137) and antibiofilm action (n = 45). Cell toxicological assessment was performed using keratinocytes and fibroblasts. Pinobanksin, chrysin, acacetin, apigenin, pinocembrin, and kaempferol-dimethyl-ether were detected. All 137 isolates were susceptible to 6.68 mg/mL or lower propolis concentration (80% isolates were susceptible to
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12020347