Gram-negative central line-associated bloodstream infection incidence peak during the summer: a national seasonality cohort study

Central line-associated bloodstream infections (CLABSI) cause increased morbidity, mortality, and hospital costs that are partially preventable. The phenomenon of seasonality among CLABSI rates has not been fully elucidated, but has implications for accurate surveillance and infection prevention tri...

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Bibliographic Details
Published in:Scientific reports 2022-03, Vol.12 (1), p.5202-7, Article 5202
Main Authors: Blot, Koen, Hammami, Naïma, Blot, Stijn, Vogelaers, Dirk, Lambert, Marie-Laurence
Format: Article
Language:English
Subjects:
692/699/255/1318
692/700/459
692/700/478/174
Ambient temperature
Bacteria
Catheter-Related Infections - epidemiology
Catheter-Related Infections - prevention & control
Cohort analysis
Cohort Studies
Cross Infection - microbiology
Epidemiology
Gram-positive bacteria
Hospital costs
Humanities and Social Sciences
Humans
Humidity
Incidence
Infections
Intensive care
Intensive Care Units
Morbidity
multidisciplinary
Population studies
Regression analysis
Relative humidity
Science
Science (multidisciplinary)
Seasonal variations
Seasons
Sepsis - complications
Summer
Surveillance
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Summary:Central line-associated bloodstream infections (CLABSI) cause increased morbidity, mortality, and hospital costs that are partially preventable. The phenomenon of seasonality among CLABSI rates has not been fully elucidated, but has implications for accurate surveillance and infection prevention trials. Longitudinal dynamic cohort of hospitals participating in hospital-wide and intensive care unit bloodstream infection surveillance for at least one full year over 2000 to 2014. Mixed-effects negative binomial regression analysis calculated the peak-to-low ratio between months as an adjusted CLABSI incidence rate ratio (IRR) with 95% confidence intervals (CI). Multivariate regression models examined the associations between CLABSI pathogens and ambient temperature and relative humidity. The study population included 104 hospital sites comprising 11,239 CLABSI. Regression analysis identified a hospital-wide increase in total CLABSI during July–August, with a higher gram-negative peak-to-low incidence rate ratio (IRR 2.52 [95% CI 1.92–3.30], p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-08973-9