Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders

Background Vascular endothelial growth factor (VEGF) is a key molecular driver of angiogenesis and vascular permeability and is expressed by a wide variety of neoplasms. Although blood VEGF concentrations have been quantified in intracranial tumors of dogs, cerebrospinal fluid (CSF) VEGF concentrati...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2021-07, Vol.35 (4), p.1873-1883
Main Authors: Mariani, Christopher L., Niman, Zachary E., Boozer, Lindsay B., Ruterbories, Laura K., Early, Peter J., Muñana, Karen R., Olby, Natasha J.
Format: Article
Language:English
Subjects:
biomarker
Brain cancer
brain tumor
Cerebrospinal fluid
Encephalitis
Magnetic resonance imaging
Meningitis
meningoencephalitis
meningomyelitis
SMALL ANIMAL
Variance analysis
Vascular endothelial growth factor
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Summary:Background Vascular endothelial growth factor (VEGF) is a key molecular driver of angiogenesis and vascular permeability and is expressed by a wide variety of neoplasms. Although blood VEGF concentrations have been quantified in intracranial tumors of dogs, cerebrospinal fluid (CSF) VEGF concentration might be a more sensitive biomarker of disease. Objective Concentrations of VEGF in CSF are higher in dogs with central nervous system (CNS) neoplasia compared to those with meningoencephalomyelitis and other neurologic disorders. Animals One hundred and twenty‐six client‐owned dogs presented to a veterinary teaching hospital. Methods Case‐control study. Cerebrospinal fluid was archived from dogs diagnosed with CNS neoplasia and meningoencephalomyelitis. Control dogs had other neurological disorders or diseases outside of the CNS. A commercially available kit was used to determine VEGF concentrations. Results Detectable CSF VEGF concentrations were present in 49/63 (77.8%) neoplastic samples, 22/24 (91.7%) inflammatory samples, and 8/39 (20.5%) control samples. The VEGF concentrations were significantly different between groups (P 
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.16181