Transcribed Ultraconserved Regions in Cancer

Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we su...

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Published in:Cells (Basel, Switzerland) Switzerland), 2022-05, Vol.11 (10), p.1684
Main Authors: Gibert, Jr, Myron K, Sarkar, Aditya, Chagari, Bilhan, Roig-Laboy, Christian, Saha, Shekhar, Bednarek, Sylwia, Kefas, Benjamin, Hanif, Farina, Hudson, Kadie, Dube, Collin, Zhang, Ying, Abounader, Roger
Format: Article
Language:English
Subjects:
Animals
Cancer
Cell cycle
Conserved Sequence - genetics
DNA
DNA methylation
Gene loci
Genome
Genomes
Leukemia
long non-coding RNA
Mice
Mutation
Neoplasms - genetics
Non-coding RNA
Proteins
Rats
Review
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
TUCR
ultraconserved
X chromosomes
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Summary:Transcribed ultraconserved regions are putative lncRNA molecules that are transcribed from DNA that is 100% conserved in human, mouse, and rat genomes. This is notable, as lncRNAs are typically poorly conserved. TUCRs remain very understudied in many diseases, including cancer. In this review, we summarize the current literature on TUCRs in cancer with respect to expression deregulation, functional roles, mechanisms of action, and clinical perspectives.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11101684